Expression of classical mediators in hearts of rats with hepatic dysfunction
Language English Country Canada Media print-electronic
Document type Journal Article
- Keywords
- bile duct ligation, cardiomyopathie cirrhotique, catecholamines, catécholamines, cirrhotic cardiomyopathy, cœur, heart, intracardiac nervous system, ligature du conduit cholédoque, lipid peroxidation, peroxydation lipidique, système nerveux intracardiaque, thioacetamide, thioacétamide,
- MeSH
- Action Potentials MeSH
- Atrial Natriuretic Factor blood metabolism MeSH
- Dopamine beta-Hydroxylase blood metabolism MeSH
- Liver Cirrhosis enzymology metabolism physiopathology MeSH
- Liver enzymology physiopathology MeSH
- Rats MeSH
- Myocardium enzymology metabolism MeSH
- Oxidative Stress MeSH
- Lipid Peroxidation MeSH
- Gene Expression Regulation * MeSH
- Heart physiology MeSH
- Muscle Contraction MeSH
- Tyrosine 3-Monooxygenase blood metabolism MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Atrial Natriuretic Factor MeSH
- Dopamine beta-Hydroxylase MeSH
- Tyrosine 3-Monooxygenase MeSH
Liver cirrhosis is associated with impairment of cardiovascular function including alterations of the heart innervation, humoral and nervous dysregulation, changes in systemic circulation and electrophysiological abnormalities. Choline acetyltransferase (ChAT), enzyme forming acetylcholine, tyrosine hydroxylase (TH), and dopamine-β-hydroxylase (DBH), enzymes participating in noradrenaline synthesis, are responsible for the production of classical neurotransmitters, and atrial natriuretic peptide (ANP) is produced by cardiomyocytes. The aim of this study was to evaluate the influence of experimentally induced hepatic dysfunction on the expression of proANP, ChAT, TH, and DBH in the heart. Hepatic dysfunction was induced by application of thioacetamide (TAA) or by ligation of bile duct. Biochemical parameters of hepatic injury and levels of peroxidation in the liver and heart were measured. Liver enzymes measured in the plasma were significantly elevated. Cardiac level of peroxidation was increased in operated but not TAA group animals. In the left atrium of operated rats, the expression of TH and DBH was lower, while expression of ChAT remained unchanged. In TAA group, no significant differences in the expression of the genes compared to controls were observed. Liver injury induced by ligation leads to an imbalance in the intracardiac innervation, which might impair nervous control of the heart.
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