Expression of classical mediators in hearts of rats with hepatic dysfunction
Jazyk angličtina Země Kanada Médium print-electronic
Typ dokumentu časopisecké články
PubMed
28746816
DOI
10.1139/cjpp-2017-0060
Knihovny.cz E-zdroje
- Klíčová slova
- bile duct ligation, cardiomyopathie cirrhotique, catecholamines, catécholamines, cirrhotic cardiomyopathy, cœur, heart, intracardiac nervous system, ligature du conduit cholédoque, lipid peroxidation, peroxydation lipidique, système nerveux intracardiaque, thioacetamide, thioacétamide,
- MeSH
- akční potenciály MeSH
- atriální natriuretický faktor krev metabolismus MeSH
- dopamin-beta-hydroxylasa krev metabolismus MeSH
- jaterní cirhóza enzymologie metabolismus patofyziologie MeSH
- játra enzymologie patofyziologie MeSH
- krysa rodu Rattus MeSH
- myokard enzymologie metabolismus MeSH
- oxidační stres MeSH
- peroxidace lipidů MeSH
- regulace genové exprese * MeSH
- srdce fyziologie MeSH
- svalová kontrakce MeSH
- tyrosin-3-monooxygenasa krev metabolismus MeSH
- zvířata MeSH
- Check Tag
- krysa rodu Rattus MeSH
- mužské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- atriální natriuretický faktor MeSH
- dopamin-beta-hydroxylasa MeSH
- tyrosin-3-monooxygenasa MeSH
Liver cirrhosis is associated with impairment of cardiovascular function including alterations of the heart innervation, humoral and nervous dysregulation, changes in systemic circulation and electrophysiological abnormalities. Choline acetyltransferase (ChAT), enzyme forming acetylcholine, tyrosine hydroxylase (TH), and dopamine-β-hydroxylase (DBH), enzymes participating in noradrenaline synthesis, are responsible for the production of classical neurotransmitters, and atrial natriuretic peptide (ANP) is produced by cardiomyocytes. The aim of this study was to evaluate the influence of experimentally induced hepatic dysfunction on the expression of proANP, ChAT, TH, and DBH in the heart. Hepatic dysfunction was induced by application of thioacetamide (TAA) or by ligation of bile duct. Biochemical parameters of hepatic injury and levels of peroxidation in the liver and heart were measured. Liver enzymes measured in the plasma were significantly elevated. Cardiac level of peroxidation was increased in operated but not TAA group animals. In the left atrium of operated rats, the expression of TH and DBH was lower, while expression of ChAT remained unchanged. In TAA group, no significant differences in the expression of the genes compared to controls were observed. Liver injury induced by ligation leads to an imbalance in the intracardiac innervation, which might impair nervous control of the heart.
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