A model of natural degradation of 17-α-ethinylestradiol in surface water and identification of degradation products by GC-MS
Jazyk angličtina Země Německo Médium print-electronic
Typ dokumentu časopisecké články
Grantová podpora
SVV 260 183
Univerzita Karlova v Praze
PubMed
28831755
DOI
10.1007/s11356-017-9743-5
PII: 10.1007/s11356-017-9743-5
Knihovny.cz E-zdroje
- Klíčová slova
- 17-Alpha-ethinylestradiol, Degradation kinetic, Endocrine disruptor, Environmental model, Natural degradation,
- MeSH
- chemické látky znečišťující vodu analýza účinky záření MeSH
- ethinylestradiol analýza účinky záření MeSH
- fotolýza MeSH
- kinetika MeSH
- mořská voda chemie MeSH
- plynová chromatografie s hmotnostně spektrometrickou detekcí MeSH
- sladká voda chemie MeSH
- světlo * MeSH
- teoretické modely MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- chemické látky znečišťující vodu MeSH
- ethinylestradiol MeSH
Over the past decade, the environment has been polluted by a wide spectrum of exogenous chemicals and environmental analysis has become one of the most progressive parts of analytical research. The aim of this work was to determine the kinetics of natural degradation, and to identify the degradation products of the massively used estrogenic drug, 17-α-ethinylestradiol. The photodegradation, oxidation and thermostability conditions were selected according to ICH requirements for pharmaceutical stability testing. A simple 72-h photodegradation study in purified water exhibited significant first-order kinetics with the kinetic constant k = 0.0303 h-1, and degradation halftime 22.8 h. The basic halftime could be reduced to 17.1 h by the addition of sea salt, and increase in temperature. Monohydroxy, dihydroxy and dehydrogenated derivatives of ethinylestradiol with intact steroidal structure were identified as major degradation products resulting from simple photodegradation. The addition of an oxidative agent significantly accelerated the degradation rate; combined with higher temperature, the degradation halftime was reduced to 1.1 h with the first-order kinetic constant k = 0.632 h-1. TOC analysis showed a notable decrease of organic mass (18% in 3 days) during oxidation experiments, and confirmed the degradation of steroidal structure.
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