Use of oral antidiabetic drugs in the treatment of maturity-onset diabetes of the young: A mini review
Language English Country Great Britain, England Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
PubMed
28840639
DOI
10.1002/dmrr.2940
Knihovny.cz E-resources
- Keywords
- MODY, diabetes, oral antidiabetic drugs, treatment,
- MeSH
- Administration, Oral MeSH
- Diabetes Mellitus, Type 2 drug therapy MeSH
- Adult MeSH
- Hypoglycemic Agents administration & dosage MeSH
- Humans MeSH
- Young Adult MeSH
- Check Tag
- Adult MeSH
- Humans MeSH
- Young Adult MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Names of Substances
- Hypoglycemic Agents MeSH
MODY (maturity-onset diabetes of the young) is a genetically linked group of clinically heterogeneous subtypes of diabetes. Roughly 5% of people with diabetes mellitus diagnosed prior to age 45 have MODY diabetes. Most of them have been erroneously diagnosed as patients with either type 1 or type 2 diabetes and, as a result, have been improperly treated. Genetic identification of MODY diabetes and its subtypes allows proper treatment and enables clinicians to switch many patients to oral antidiabetic agents, mainly sulphonylureas. However, some new classes of oral antidiabetic drugs have also been tested and found to be effective in MODY patients. We have searched for research articles and case reports written in full-text English or with an English abstract, using the following keywords: MODY and oral antidiabetic* in the databases Cochrane Library, PubMed, and Science Direct. Therapeutic options using currently standardized oral antidiabetic drugs (mainly sulphonylureas), as well as more experimental treatment with other classes of oral antidiabetic drugs in different types of MODY, are discussed, with special focus on the therapy of the most common MODY subtypes, including specific conditions such as pregnancy. This review article summarizes the currently available information about oral antidiabetic treatment of patients with MODY diabetes.
Department of Internal Medicine Charles University 2nd Faculty of Medicine Prague Czech Republic
References provided by Crossref.org
How can maturity-onset diabetes of the young be identified among more common diabetes subtypes?
Hidden MODY-Looking for a Needle in a Haystack
