Changes of patient-reported outcomes and protein fingerprint biomarkers after exercise therapy for axial spondyloarthritis
Jazyk angličtina Země Německo Médium print-electronic
Typ dokumentu časopisecké články
Grantová podpora
Project for Conceptual Development for the institution of the Ministry of Health Czech Republic - Institute of Rheumatology (number 023728),
Ministerstvo Zdravotnictví Ceské Republiky
GAUK number 214615
Grantová Agentura, Univerzita Karlova
SVV for FTVS 2017 - number 260466
Charles University, Faculty of Physical Education and Sports
Programme of the institutional support for the development of science at Charles University Progress, No. Q41 Biological aspects of the investigation of human movement
Charles University, Faculty of Physical education and Sport
PubMed
28856518
DOI
10.1007/s10067-017-3802-7
PII: 10.1007/s10067-017-3802-7
Knihovny.cz E-zdroje
- Klíčová slova
- axial spondyloarthritis, exercise therapy, extracellular matrix, matrix metalloproteinase,
- MeSH
- biologické markery analýza MeSH
- C-reaktivní protein analýza MeSH
- dospělí MeSH
- hodnocení výsledků péče pacientem * MeSH
- kvalita života MeSH
- lidé MeSH
- matrixové metaloproteinasy analýza MeSH
- peptidové mapování MeSH
- spondylartritida rehabilitace MeSH
- terapie cvičením * MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- biologické markery MeSH
- C-reaktivní protein MeSH
- matrixové metaloproteinasy MeSH
The objective of this study was to investigate the patient-reported outcomes (PROs) and matrix metalloproteinase (MMP) derived extracellular matrix (ECM) biomarkers in non-radiographic (nr)-axial spondyloarthritis (axSpA) and radiographic (r)-axSpA after exercise intervention. Forty-six axSpA patients with stable disease and treatment underwent 24 weeks long exercise intervention. The clinical and laboratory assessments were performed at baseline and at follow-up. The PROs included evaluation of patient's global disease activity (PGDA), disease activity (DA7), pain (PAIN7) and fatigue during last week and quality of life questionnaires. ELISAs for MMP-degraded collagen type II, C-reactive protein (CRPM) and citrullinated vimentin were used. The data of 23 r-axSpA and 19 nr-axSpA were analysed. The PDGA was similar for nr-axSpA (35.2 ± 18.9) and r-axSpA (33.4 ± 22.3) at baseline, improved significantly after intervention (p < 0.01) and the change of PDGA was almost identical for nr-axSpA (- 10.0 ± 15.4) and r-axSpA (- 9.8 ± 11.9). Evaluations of DA7 and PAIN7 were significantly improved only in nr-axSpA (3.5 ± 2.3 and 34.7 ± 25.6 at baseline vs. 2.1 ± 1.9 and 21.0 ± 20.5, respectively, p < 0.01). The decline of DA7 and PAIN7 was more profound, but not significantly in nr-axSpA than in r-axSpA (- 1.4 ± 1.6 and - 13.7 ± 17.4 vs. - 0.5 ± 3.1 and - 3.7 ± 3.3, respectively). The quality of life was not changed. At baseline, increased levels of CRPM were found in r-axSpA (14.85 ± 4.10) compared to nr-axSpA (11.83 ± 3.20), p < 0.05, but all three biomarkers were not influenced by exercise therapy. We found that exercise therapy mainly in the nr-axSpA improves PROs, but not ECM turnover biomarkers. This indicates that exercise therapy is important for patients' health but does not affect ECM turnover.
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