Iterative Photoinduced Chain Functionalization as a Generic Platform for Advanced Polymeric Drug Delivery Systems
Language English Country Germany Media print-electronic
Document type Journal Article
- Keywords
- drug delivery systems, functionalization of polymers, photochemistry, polyesters, stimuli-responsive polymers,
- MeSH
- Alkynes chemistry MeSH
- Photochemical Processes * MeSH
- HEK293 Cells MeSH
- Curcumin administration & dosage chemistry MeSH
- Drug Delivery Systems methods MeSH
- Humans MeSH
- Cell Line, Tumor MeSH
- Nanostructures administration & dosage chemistry MeSH
- Polyesters chemistry MeSH
- Polyethylene Glycols chemistry MeSH
- Antineoplastic Agents administration & dosage chemistry MeSH
- Sulfhydryl Compounds chemistry MeSH
- Cell Survival drug effects MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Alkynes MeSH
- Curcumin MeSH
- poly(epsilon-caprolactone)-poly(oxyethylene)-poly(epsilon-caprolactone) MeSH Browser
- Polyesters MeSH
- Polyethylene Glycols MeSH
- Antineoplastic Agents MeSH
- Sulfhydryl Compounds MeSH
Advanced drug delivery systems (DDS) are easily designed following a photoiterative strategy. Multifunctional polymers are obtained by coupling building blocks of interest to an alkynated poly(ε-caprolactone) (PCL) platform via an efficient thiol-yne photoaddition. Fine-tuning over the design is achieved, as illustrated with targeting and enzyme-responsive DDS.
IBMM Univ Montpellier CNRS ENSCM Montpellier France
INSERM U1209 Institut Albert Bonniot Université Grenoble Alpes F 38000 Grenoble France
Laboratory of applied Chemistry Faculty of Science 3 Lebanese University P O Box 826 Tripoli Lebanon
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