Effect of six oximes on acutely anticholinesterase inhibitor-induced oxidative stress in rat plasma and brain
Jazyk angličtina Země Německo Médium print-electronic
Typ dokumentu časopisecké články
Grantová podpora
Project No. III46009
Ministry of Education, Science and Technological Development of the Republic of Serbia
OI 175035
Ministry of Education, Science and Technological Development of the Republic of Serbia
No. 2110
Specific Research Project of Faculty of Science, University of Hradec Kralove
2016
Specific Research Project of Faculty of Science, University of Hradec Kralove
8F17004
Ministry of Education, Youth and Sports
PubMed
29098328
DOI
10.1007/s00204-017-2101-z
PII: 10.1007/s00204-017-2101-z
Knihovny.cz E-zdroje
- Klíčová slova
- Antioxidats, Dichlorvos, Efficacy, Oxime K027, Oxime K203, Pro-oxidants,
- MeSH
- aryldialkylfosfatasa krev MeSH
- biologické markery krev MeSH
- cholinesterasové inhibitory farmakologie MeSH
- dichlorvos toxicita MeSH
- krysa rodu Rattus MeSH
- malondialdehyd krev MeSH
- mozek účinky léků MeSH
- obidoxim chlorid farmakologie MeSH
- otrava organofosfáty farmakoterapie MeSH
- oxidační stres účinky léků MeSH
- oximy farmakologie MeSH
- pralidoximové sloučeniny MeSH
- pyridinové sloučeniny farmakologie MeSH
- superoxiddismutasa krev MeSH
- trimedoxim farmakologie MeSH
- zvířata MeSH
- Check Tag
- krysa rodu Rattus MeSH
- mužské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- aryldialkylfosfatasa MeSH
- asoxime chloride MeSH Prohlížeč
- biologické markery MeSH
- cholinesterasové inhibitory MeSH
- dichlorvos MeSH
- malondialdehyd MeSH
- obidoxim chlorid MeSH
- oximy MeSH
- Pon1 protein, rat MeSH Prohlížeč
- pralidoxime MeSH Prohlížeč
- pralidoximové sloučeniny MeSH
- pyridinové sloučeniny MeSH
- superoxiddismutasa MeSH
- trimedoxim MeSH
Beside the key inhibition of acetylcholinesterase (AChE), involvement of oxidative stress in organophosphate (OP)-induced toxicity has been supported by experimental and human studies. On the other hand, according to our best knowledge, possible antioxidant properties of oximes, the only causal antidotes to OP-inhibited AChE, have been examined only by a few studies. Thus, we have determined the effect of four conventional (obidoxime, trimedoxime, pralidoxime, asoxime) and two promising experimental oximes (K027, K203) on dichlorvos (DDVP)-induced oxidative changes in vivo. Wistar rats (5/group) were treated with oxime (5% LD50 i.m) immediately after DDVP challenge (75% LD50 s.c). Oxidative stress biomarkers were determined in plasma and brain 60 min after the treatment: prooxidative-superoxide anion (O2·-) and total oxidative status (TOS); antioxidative-superoxide dismutase (SOD), total thiol (SH) groups, total antioxidant status (TAS) and paraoxonase (PON1); tissue oxidative stress burden-prooxidative-antioxidative balance (PAB) and oxidative stress index (OSI); oxidative tissue damage-malondialdehyde (MDA) and advanced oxidation protein products (AOPP). All oximes were able to attenuate DDVP-induced oxidative stress in rat plasma and brain. Changes of determined parameters in brain were not as prominent as it was seen in plasma. Based on OSI, better abilities of oxime K027, K203 and obidoxime to maintain DDVP-induced oxidative stress in rat brain were shown as compared to trimedoxime, pralidoxime and asoxime. Oximes can influence the complex in vivo redox processes that might contribute to their overall therapeutic efficacy. Further research is needed to understand the underlying molecular mechanisms involved in this phenomenon.
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