Cardiac resynchronisation therapy optimisation of interventricular delay by the systolic dyssynchrony index: A comparative, randomised, 12-month follow-up study
Jazyk angličtina Země Nizozemsko Médium print-electronic
Typ dokumentu časopisecké články, randomizované kontrolované studie
PubMed
29146543
DOI
10.1016/j.hjc.2017.11.003
PII: S1109-9666(17)30455-4
Knihovny.cz E-zdroje
- Klíčová slova
- 3D echocardiography, cardiac resynchronisation therapy, systolic dyssynchrony index,
- MeSH
- časové faktory MeSH
- echokardiografie trojrozměrná metody MeSH
- elektrokardiografie MeSH
- funkce levé komory srdeční fyziologie MeSH
- kvalita života MeSH
- lidé MeSH
- následné studie MeSH
- převodní systém srdeční patofyziologie MeSH
- prospektivní studie MeSH
- senioři MeSH
- srdeční arytmie diagnóza patofyziologie terapie MeSH
- srdeční komory diagnostické zobrazování patofyziologie MeSH
- srdeční resynchronizační terapie metody MeSH
- systola MeSH
- výsledek terapie MeSH
- zátěžový test MeSH
- Check Tag
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- randomizované kontrolované studie MeSH
BACKGROUND: The aim of our study was to compare the effect of interventricular (VV) delay optimisation in CRT recipients on the basis of systolic dyssynchrony index (SDI) derived from the three-dimensional echocardiography (3DE) versus QRS width assessment on left ventricle volume reduction at the 12-month follow-up. METHODS: We included 63 patients with recently implanted CRT in this randomised, open-label trial. Patients were randomised to VV delay optimisation according to QRS complex width measurement in group 1 (n = 31) to obtain the narrowest QRS complex and SDI in group 2 (n = 32) to achieve its lowest possible value. We evaluated left ventricular end-systolic volume (LVESv), left ventricular ejection fraction (LVEF) and SDI by 3DE before CRT implantation and at a 12-month follow-up in all the patients. We also obtained the New York Heart Association functional class, the 6-minute walk test, the quality of life questionnaire and the level of NT-proBNP. RESULTS: The number of volumetric responders was similar in both groups (17 vs. 20, P = 0.786). There were also no significant differences in the reduction of LVESv (-41 ± 55 mL vs. - 61 ± 51 mL, P = 0.111), improvement in LVEF (+10.1 ± 10.6% vs. + 13.0 ± 9.9%, P = 0.213) or differences in clinical outcomes between both groups at the 12-month follow-up. CONCLUSION: CRT optimisation of interventricular delay using SDI compared with QRS width assessment did not reveal any significant difference in terms of volumetric and clinical response at the 12-month follow-up.
Department of Cardiology Pardubice Regional Hospital a s Pardubice Czech Republic
Institute of Biostatistics and Analyses Faculty of Medicine Masaryk University Brno Czech Republic
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