Úloha T-regulačních lymfocytů v patogenezi předčasného porodu
[The role of T-regulatory lymphocytes in pathogenesis of preterm delivery]
Language Czech Country Czech Republic Media print
Document type Journal Article
PubMed
29302984
PII: 62464
- Keywords
- T-regulatory cells, premature birth immunomodulation in pregancy.,
- MeSH
- Immunomodulation MeSH
- Humans MeSH
- Infant, Newborn MeSH
- Fetus immunology MeSH
- Premature Birth physiopathology MeSH
- T-Lymphocytes, Regulatory immunology metabolism MeSH
- Pregnancy MeSH
- Check Tag
- Humans MeSH
- Infant, Newborn MeSH
- Pregnancy MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
OBJECTIVE: To describe the role of T-regulatory lymphocytes in pathogenesis of preterm delivery. SETTING: Department of Obstetrics and Gynecology, General University Hospital and 1st Medical Faculty, Charles University, Prague. METHOD: T-regulatory lymphocytes modulate the immune system, secure the tolerance to own antigens and prevent autoimmune disease. During pregnancy is maternal immunity in contact with the semi-allogeneic fetus due to the fetomaternal crosstalk. It seems that maternal immunity and T-regulatory lymphocytes have an effect on premature birth and other pregnancy pathologies. According to the latest data, their role in the immunomodulation of pregnant women seems to be very significant, although we still do not understand many mechanisms.
