High hydrostatic pressure in cancer immunotherapy and biomedicine
Language English Country England, Great Britain Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
PubMed
29409785
DOI
10.1016/j.biotechadv.2018.01.015
PII: S0734-9750(18)30015-6
Knihovny.cz E-resources
- Keywords
- Cancer, Dendritic cell, High hydrostatic pressure, Immunotherapy, Orthopedic surgery, Vaccine, Virus inactivation,
- MeSH
- Biotechnology instrumentation methods MeSH
- Dendritic Cells immunology MeSH
- Eukaryotic Cells MeSH
- Hydrostatic Pressure * MeSH
- Immunotherapy methods MeSH
- Virus Inactivation MeSH
- Humans MeSH
- Neoplasms pathology therapy MeSH
- Orthopedic Procedures methods MeSH
- Vaccines immunology MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Names of Substances
- Vaccines MeSH
High hydrostatic pressure (HHP) has been known to affect biological systems for >100 years. In this review, we describe the technology of HHP and its effect macromolecules and physiology of eukaryotic cells. We discuss the use of HHP in cancer immunotherapy to kill tumor cells for generation of whole cell and dendritic cell-based vaccines. We further summarize the current use and perspectives of HHP application in biomedicine, specifically in orthopedic surgery and for the viral, microbial and protozoan inactivation to develop vaccines against infectious diseases.
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