Polyhedral carboxymethyl carborane (C2 B10 H12 ) derivatives, including mono- and disubstituted o-, m-, and p-isomers, have been synthesized. Supramolecular host-guest complexation of these derivatives with cyclodextrins (CDs; namely, α-, β-, and γ-CD) has been investigated in water. The globular structure of the carborane binding moiety and its hydrophobic character qualify it as an ideal recognition site to form stable inclusion complexes with macrocyclic host molecules in aqueous solution. The measured binding affinities for the carborane derivatives were in the millimolar range (Ka =103 -104 m-1 ) with differently sized CDs, and preferential binding to β-CD.

Department of Organic Chemistry Faculty of Science Charles University Hlavova 2030 128 42 Prague 2 Czech Republic

Institute of Inorganic Chemistry Academy of Sciences of the Czech Republic v v i Hlavní 1001 250 68 Řež Czech Republic

Jacobs University Bremen Department of Life Sciences and Chemistry Campus Ring 1 28759 Bremen Germany

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Face-Fusion of Icosahedral Boron Hydride Increases Affinity to γ-Cyclodextrin: closo,closo-[B21 H18 ]- as an Anion with Very Low Free Energy of Dehydration