Why is the hydrolytic activity of acetylcholinesterase pH dependent? Kinetic study of acetylcholine and acetylthiocholine hydrolysis catalyzed by acetylcholinesterase from electric eel
Language English Country Germany Media print
Document type Journal Article
PubMed
29936491
DOI
10.1515/znc-2017-0134
PII: znc-2017-0134
Knihovny.cz E-resources
- Keywords
- acetylcholinesterase, enzyme activity, kinetics, pH dependence,
- MeSH
- Acetylcholine metabolism MeSH
- Acetylcholinesterase metabolism MeSH
- Acetylthiocholine metabolism MeSH
- Electrophorus metabolism MeSH
- Hydrolysis MeSH
- Catalysis MeSH
- Kinetics MeSH
- Hydrogen-Ion Concentration MeSH
- Fish Proteins metabolism MeSH
- Animals MeSH
- Check Tag
- Animals MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Acetylcholine MeSH
- Acetylcholinesterase MeSH
- Acetylthiocholine MeSH
- Fish Proteins MeSH
See more in PubMed
Giacobini E. Cholinesterases and cholinesterase inhibitors. London: Martin Dunitz Ltd., 2000.
Iyo M, Namba H, Fukushi K, Shinotoh H, Nagatsuka S, Suhara T, et al. Measurement of acetylcholinesterase by positron emission tomography in the brains of healthy controls and patients with Alzheimer’s disease. Lancet 1997;349:1805–9. DOI
Anand P, Singh B. A review on cholinesterase inhibitors for Alzheimer’s disease. Arch Pharm Res 2013;36:375–99. DOI
Zdražilová P, Štěpánková Š, Komersová A, Vránová M, Komers K, Čegan A. Kinetics of 13 new cholinesterase inhibitors. Z Naturforsch 2006;61c:611–7. DOI
Kovářová M, Komers K, Štěpánková Š, Čegan A. Inhibition of acetylcholinesterase by 14 achiral and five chiral imidazole derivates. Bioresour Technol 2010;101:6281–3. DOI
Bergmann F, Rimon S, Segal R. Effect of pH on the activity of eel esterase towards different substrates. Biochem J 1958;68: 493–9. DOI
Silman HI, Karlin A. Effect of local pH changes caused by substrate hydrolysis on the activity of membrane-bound acetylcholinesterase. Proc Natl Acad Sci USA 1967;58:1664–8. DOI
Mdegela RH, Mosha RS, Sandvik M, Skaare JU. Assessment of acetylcholinesterase activity in Clarias gariepinus as a biomarker of organophosphate and carbamate exposure. Ecotoxicology 2010;19:855–63. DOI
Štěpánková Š, Vránová M, Zdražilová P, Komers K, Komersová A, Čegan A. Two new methods monitoring kinetics of hydrolysis of acetylcholine and acetylthiocholine. Z Naturforsch 2005;60c:943–6. DOI
Zdražilová P, Štěpánková Š, Vránová M, Komers K, Komersová A, Čegan A. Kinetics of total enzymatic hydrolysis of acetylcholine and acetylthiocholine. Z Naturforsch 2006;61c:289–94. DOI
Michaelis L, Menten ML. Die kinetik der invertinwirkung. Biochem Z 1913;49:333–69.
Ritter P. Biochemistry. Pacific Grove, CA, USA: Brooks/Cole Publishing Company, 1966.
Ellman GL, Courtney KD, Andres V Jr, Featherstone RM. A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem Pharmacol 1961;7:88–95. DOI