31P-MR spectroscopy in patients with mild and serious lower limb ischemia
Language English Country Italy Media print-electronic
Document type Journal Article
PubMed
29644834
DOI
10.23736/s0392-9590.18.03943-3
PII: S0392-9590.18.03943-3
Knihovny.cz E-resources
- MeSH
- Exercise MeSH
- Lower Extremity blood supply MeSH
- Ischemia complications MeSH
- Diabetes Complications MeSH
- Muscle, Skeletal blood supply MeSH
- Middle Aged MeSH
- Humans MeSH
- Magnetic Resonance Spectroscopy * MeSH
- Rest MeSH
- Peripheral Vascular Diseases diagnostic imaging MeSH
- Aged MeSH
- Case-Control Studies MeSH
- Check Tag
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
BACKGROUND: 31P-MR spectroscopy is a technique for undertaking a comprehensive evaluation of muscle metabolism. The goal of this study was to compare patients with mild and severe lower limb ischemia measured by 31P-MR spectroscopy at rest and during exercise. METHODS: Sixteen non-diabetic mild peripheral arterial occlusive disease (PAOD) patients, 23 diabetic PAOD patients with severe ischemia and 19 healthy controls were examined by rest and dynamic 31P-MR spectroscopy with a 3T MR system equipped with an MR-compatible home-made pedal ergometer. Signal intensity ratios of phosphorous metabolites to the sum of all 31P intensities (Ptot) and pH were obtained at rest. The PCr drop (ΔPCr), time recovery constant of PCr (τPCr), pH at the end of the exercise (pHend), and mitochondrial capacity (Qmax) were calculated from dynamic MR spectra. RESULTS: Diabetic PAOD patients with severe ischemia differed from controls in both rest (PCr/Pi, βATP/Ptot, pH) and dynamic (Qmax, pHend, τPCr) parameters. PAOD patients with mild ischemia differed from controls only in Qmax and pHend. Rest parameters of the nondiabetic PAOD patients did not differ from control values excluding rest pH which was higher in both patient groups. CONCLUSIONS: A combination of rest and dynamic 31P-MR spectroscopy can distinguish among all three groups of subjects. On the other hand, examination at rest is sufficient for differentiation between patient groups and verification of severe ischemia.
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