Aldosterone and aldosterone/cortisol ratio is higher in serum of long-term compared to first episode schizophrenia patients: A pilot study
Language English Country England, Great Britain Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
29940461
DOI
10.1016/j.jpsychires.2018.06.012
PII: S0022-3956(18)30187-0
Knihovny.cz E-resources
- Keywords
- Aldosterone, Cortisol, First episode, Long-term schizophrenia,
- MeSH
- Aldosterone blood MeSH
- Antipsychotic Agents therapeutic use MeSH
- Adult MeSH
- Hydrocortisone blood MeSH
- Correlation of Data MeSH
- Humans MeSH
- Longitudinal Studies MeSH
- Pilot Projects MeSH
- Psychiatric Status Rating Scales MeSH
- Schizophrenia blood drug therapy MeSH
- Check Tag
- Adult MeSH
- Humans MeSH
- Male MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Aldosterone MeSH
- Antipsychotic Agents MeSH
- Hydrocortisone MeSH
We have previously shown that patients with severe depressive episode exhibit higher aldosterone concentrations compared to those with moderate depressive episode. The present study was undertaken to test the hypothesis that circulating concentration of aldosterone reflect the clinical state in patients with schizophrenia. The sample consisted of 36 hospitalized patients (25 men, 11 women) with the first episode or long-term course of schizophrenia. The severity of psychopathology was evaluated using the Positive and Negative Syndrome Scale (PANSS). Samples for measurement of serum aldosterone were obtained immediately after awakening. The results showed that serum aldosterone concentrations were lower in patients with the first episode compared to those in patients with long-term course of schizophrenia. Importantly, lower aldosterone concentrations observed in patients with the first episode were associated with more severe clinical symptoms as indicated by all subscales of PANSS. Serum cortisol concentrations did not differ between the groups, while the aldosterone/cortisol ratio showed similar pattern as aldosterone concentrations. The present pilot study suggests that circulating aldosterone in patients with schizophrenia may reflect the severity of clinical symptoms but in an opposite direction than in patients with major depressive disorder.
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