Management and outcome of colorectal cancer during pregnancy: report of 41 cases
Language English Country Great Britain, England Media print-electronic
Document type Journal Article, Observational Study
- Keywords
- Colon, cancer, outcome, pregnancy, rectum, treatment,
- MeSH
- Chemotherapy, Adjuvant MeSH
- Adult MeSH
- Cohort Studies MeSH
- Colorectal Neoplasms mortality pathology surgery MeSH
- Combined Modality Therapy MeSH
- Humans MeSH
- Neoplasm Recurrence, Local mortality MeSH
- Survival Rate MeSH
- Pregnancy Complications, Neoplastic mortality pathology surgery MeSH
- Infant, Newborn MeSH
- Birth Weight MeSH
- Registries MeSH
- Neoplasm Staging MeSH
- Pregnancy MeSH
- Pregnancy Outcome MeSH
- Check Tag
- Adult MeSH
- Humans MeSH
- Infant, Newborn MeSH
- Pregnancy MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Observational Study MeSH
- Geographicals
- Czechoslovakia MeSH
BACKGROUND: Colorectal cancer in pregnancy is rare, with an incidence of 0.8 per 100,000 pregnancies. Advanced disease (stage III or IV) is diagnosed more frequently in pregnant patients. We aimed to review all cases of colorectal cancer in pregnancy from the International Network on Cancer, Infertility and Pregnancy database in order to learn more about this rare disease and improve its management. METHODS: Data on the demographic features, symptoms, histopathology, diagnostic and therapeutic interventions and outcomes (obstetric, neonatal and maternal) were analysed. RESULTS: Twenty-seven colon and 14 rectal cancer cases were identified. Advanced disease was present in 30 patients (73.2%). During pregnancy, 21 patients (51.2%) received surgery and 12 patients (29.3%) received chemotherapy. Thirty-three patients (80.5%) delivered live babies: 21 by caesarean section and 12 vaginally. Prematurity rate was high (78.8%). Eight babies were small for gestational age (27.6%). Three patients (10.7%) developed recurrence of disease. Overall 2-year survival was 64.4%. CONCLUSION: Despite a more frequent presentation with advanced disease, colorectal cancer has a similar prognosis in pregnancy when compared with the general population. Diagnostic interventions and treatment should not be delayed due to the pregnancy but a balance between maternal and foetal wellbeing must always be kept in mind.
b Department of Obstetrics and Gynaecology VU University Medical Centre Amsterdam Netherlands
c Department of Oncology KU Leuven Leuven Belgium
e Department of Gynaecological Surgery Institute Gustave Roussy Villejuif France
j Division of Gynaecologic Oncology University Hospitals Leuven Leuven Belgium
k Centre for Gynaecologic Oncology Amsterdam Academic Medical Centre Amsterdam Netherlands
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