Immunohistochemical and selected genetic reflex testing of all uterine leiomyosarcomas and STUMPs for ALK gene rearrangement may provide an effective screening tool in identifying uterine ALK-rearranged mesenchymal tumors
Jazyk angličtina Země Německo Médium print-electronic
Typ dokumentu časopisecké články
PubMed
30116888
DOI
10.1007/s00428-018-2428-8
PII: 10.1007/s00428-018-2428-8
Knihovny.cz E-zdroje
- Klíčová slova
- ALK, IMT, Leiomyosarcoma, Molecular genetics, STUMP,
- MeSH
- anaplastická lymfomová kináza MeSH
- genetické testování metody MeSH
- genová přestavba * MeSH
- imunohistochemie MeSH
- leiomyosarkom diagnóza genetika metabolismus MeSH
- lidé MeSH
- nádor z hladké svalové tkáně diagnóza genetika metabolismus MeSH
- nádorové biomarkery genetika metabolismus MeSH
- nádory dělohy diagnóza genetika metabolismus MeSH
- retrospektivní studie MeSH
- tyrosinkinasové receptory genetika metabolismus MeSH
- Check Tag
- lidé MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- ALK protein, human MeSH Prohlížeč
- anaplastická lymfomová kináza MeSH
- nádorové biomarkery MeSH
- tyrosinkinasové receptory MeSH
We examined the value of targeted molecular screening for the identification of uterine anaplastic lymphoma kinase (ALK)-rearranged mesenchymal tumors, including ALK immunohistochemistry followed by molecular genetic testing, in all uterine leiomyosarcomas and STUMPs (smooth muscle tumors of uncertain malignant potential). All leiomyosarcoma and STUMP cases diagnosed in a 10-year period (2006-2016) at Charles University Faculty of Medicine in Pilsen were retrieved and reviewed. Of 23 cases, one case (LMS [leiomyosarcoma]) was positive for ALK rearrangement, namely, PPP1CB-ALK fusion gene. No specific histologic features (i.e., lymphocytic infiltrate and stromal edema) were observed in this case. This suggests that inflammatory myofibroblastic tumor (IMT)-like histologic features may not be an initial reliable screening tool in identifying uterine IMT cases. Thus, we proposed a two-step IHC and molecular genetic testing (as a reflex test) for IMT in all uterine LMS and STUMP cases. This will enhance the proper detection of such tumors at the population level and ultimately offer patients available targeted therapies.
Bioptická laboratoř s r o Pilsen Czech Republic
Cytopathos s r o Bratislava Slovak Republic
Department of Pathology Royal Columbian Hospital University of British Columbia Vancouver BC Canada
Department of Pathology Slovak Medical University in Bratislava Bratislava Slovak Republic
Faculty of Education University of West Bohemia Pilsen Czech Republic
Zobrazit více v PubMed
Am J Surg Pathol. 2018 May 22;:null PubMed
Br J Haematol. 2015 Mar;168(6):771-83 PubMed
J Hematol Oncol. 2015 Jun 11;8:66 PubMed
Am J Surg Pathol. 2016 May;40(5):599-607 PubMed
Am J Surg Pathol. 2017 Oct;41(10):1433-1442 PubMed
Mod Pathol. 2018 May;31(5):816-828 PubMed
Hum Pathol. 2018 Oct 4;:null PubMed
Am J Surg Pathol. 2017 Jan;41(1):12-24 PubMed
Am J Surg Pathol. 2018 May;42(5):561-568 PubMed
Am J Surg Pathol. 2016 Mar;40(3):285-301 PubMed
Nat Med. 2014 Dec;20(12):1479-84 PubMed
Nature. 2013 May 2;497(7447):67-73 PubMed
Mod Pathol. 2001 Jun;14(6):569-76 PubMed
Mod Pathol. 2017 Oct;30(10):1489-1503 PubMed
BMJ Case Rep. 2016 Aug 16;2016: PubMed
