Sulfobetaines Meet Carboxybetaines: Modulation of Thermo- and Ion-Responsivity, Water Structure, Mechanical Properties, and Cell Adhesion
Language English Country United States Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
- MeSH
- Betaine analogs & derivatives chemistry MeSH
- Cell Adhesion drug effects MeSH
- 3T3 Cells MeSH
- Hydrogels chemical synthesis chemistry pharmacology MeSH
- Hydrogen-Ion Concentration MeSH
- Polymethacrylic Acids chemical synthesis chemistry pharmacology MeSH
- Mice MeSH
- Osmolar Concentration MeSH
- Polymerization MeSH
- Transition Temperature MeSH
- Viscoelastic Substances chemical synthesis chemistry pharmacology MeSH
- Water chemistry MeSH
- Animals MeSH
- Check Tag
- Mice MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Betaine MeSH
- Hydrogels MeSH
- Polymethacrylic Acids MeSH
- sulfobetaine MeSH Browser
- Viscoelastic Substances MeSH
- Water MeSH
A procedure for the preparation of copolymers bearing sulfobetaine and carboxybetaine methacrylic-based monomers by free-radical polymerization is described and discussed. A combination of monomers affects the upper critical solution temperature (UCST) in water and in the presence of a simple NaCl electrolyte while retaining the zwitterionic character. In addition, hydrogel samples were prepared and showed tunable water structure and mechanical properties. The total nonfreezable water content decreases with the amount of carboxybetaine segment in the hydrogel feed and the compression moduli were in a range of 0.7-1.6 MPa. Responses to external conditions such as temperature and ion strength were investigated and a potential application such as modulated thermal detection is proposed. The presence of the carboxylate group in the carboxybetaine segment enables a small fluorescence probe and peptide bearing RDG motif to be attached to polymer and hydrogel samples, respectively. The hydrogel samples functionalized with the RGD motif exhibit controlled cell adhesion. Such synthetic strategy based on combination of different zwitterionic segments offers a simple pathway for the development of zwitterionic materials with programmable properties.
Center for Advanced Materials Qatar University P O Box 2713 Doha Qatar
Polymer Institute Slovak Academy of Sciences Dúbravská cesta 9 84541 Bratislava Slovak Republic
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