The European Network for Breast Development and Cancer (ENBDC), a worldwide network ( http://www.enbdc.org/ ), celebrated its tenth anniversary with a fantastic meeting last March 15-17, 2018 in Weggis with 76 attendees.

Cancer Epigenetics and Biology Program Avinguda de la Gran Via 199 203 L'Hospitalet deLlobregat 08908 Barcelona Spain

Cancer Research UK Cambridge Cancer Centre Cambridge CB2 0RE UK

Department of Biomedicine University of Basel University Hospital Basel Hebelstrasse 20 CH 4031 Basel Switzerland

Department of Histology and Embryology Faculty of Medicine Masaryk University Kamenice 126 3 625 00 Brno Czech Republic

Department of Pharmacology University of Cambridge Cambridge CB2 1PD UK

Institute of Biotechnology and HiLIFE University of Helsinki Helsinki Finland

The Breast Cancer Now Toby Robins Research Centre The Institute of Cancer Research London UK

Zobrazit více v PubMed

Nguyen QH, Pervolarakis N, Blake K, Ma D, Davis RT, James N, Phung AT, Willey E, Kumar R, Jabart E, et al. Profiling human breast epithelial cells using single cell RNA sequencing identifies cell diversity. Nat Commun. 2018;9(1):2028. doi: 10.1038/s41467-018-04334-1. PubMed DOI PMC

Bach K, Pensa S, Grzelak M, Hadfield J, Adams DJ, Marioni JC, Khaled WT. Differentiation dynamics of mammary epithelial cells revealed by single-cell RNA sequencing. Nat Commun. 2017;8(1):2128. doi: 10.1038/s41467-017-02001-5. PubMed DOI PMC

Pal B, Chen Y, Vaillant F, Jamieson P, Gordon L, Rios AC, Wilcox S, Fu N, Liu KH, Jackling FC, et al. Construction of developmental lineage relationships in the mouse mammary gland by single-cell RNA profiling. Nat Commun. 2017;8(1):1627. doi: 10.1038/s41467-017-01560-x. PubMed DOI PMC

Lawson DA, Bhakta NR, Kessenbrock K, Prummel KD, Yu Y, Takai K, Zhou A, Eyob H, Balakrishnan S, Wang CY, et al. Single-cell analysis reveals a stem-cell program in human metastatic breast cancer cells. Nature. 2015;526(7571):131–135. doi: 10.1038/nature15260. PubMed DOI PMC

Casbon AJ, Reynaud D, Park C, Khuc E, Gan DD, Schepers K, Passegue E, Werb Z. Invasive breast cancer reprograms early myeloid differentiation in the bone marrow to generate immunosuppressive neutrophils. Proc Natl Acad Sci U S A. 2015;112(6):E566–E575. doi: 10.1073/pnas.1424927112. PubMed DOI PMC

Gonzalez H, Robles I, Werb Z. Innate and acquired immune surveillance in the postdissemination phase of metastasis. FEBS J. 2017;285(4):654–664. doi: 10.1111/febs.14325. PubMed DOI PMC

Schedin P, Keely PJ. Mammary gland ECM remodeling, stiffness, and mechanosignaling in normal development and tumor progression. Cold Spring Harb Perspect Biol. 2011;3(1):a003228. doi: 10.1101/cshperspect.a003228. PubMed DOI PMC

Elosegui-Artola A, Oria R, Chen Y, Kosmalska A, Perez-Gonzalez C, Castro N, Zhu C, Trepat X, Roca-Cusachs P. Mechanical regulation of a molecular clutch defines force transmission and transduction in response to matrix rigidity. Nat Cell Biol. 2016;18(5):540–548. doi: 10.1038/ncb3336. PubMed DOI

Elosegui-Artola A, Andreu I, Beedle AEM, Lezamiz A, Uroz M, Kosmalska AJ, Oria R, Kechagia JZ, Rico-Lastres P, Le Roux AL, et al. Force triggers YAP nuclear entry by regulating transport across nuclear pores. Cell. 2017;171(6):1397–1410. doi: 10.1016/j.cell.2017.10.008. PubMed DOI

Hannezo E, Scheele C, Moad M, Drogo N, Heer R, Sampogna RV, van Rheenen J, Simons BD. A unifying theory of branching morphogenesis. Cell. 2017;171(1):242–255. doi: 10.1016/j.cell.2017.08.026. PubMed DOI PMC

Scheele CL, Hannezo E, Muraro MJ, Zomer A, Langedijk NS, van Oudenaarden A, Simons BD, van Rheenen J. Identity and dynamics of mammary stem cells during branching morphogenesis. Nature. 2017;542(7641):313–317. doi: 10.1038/nature21046. PubMed DOI PMC

Bresson L, Faraldo MM, Di-Cicco A, Quintanilla M, Glukhova MA, Deugnier MA. Podoplanin regulates mammary stem cell function and tumorigenesis by potentiating Wnt/beta-catenin signaling. Development. 2018;145(4):dev160382. PubMed

Havas KM, Milchevskaya V, Radic K, Alladin A, Kafkia E, Garcia M, Stolte J, Klaus B, Rotmensz N, Gibson TJ, et al. Metabolic shifts in residual breast cancer drive tumor recurrence. J Clin Invest. 2017;127(6):2091–2105. doi: 10.1172/JCI89914. PubMed DOI PMC

Wynn TA, Chawla A, Pollard JW. Macrophage biology in development, homeostasis and disease. Nature. 2013;496(7446):445–455. doi: 10.1038/nature12034. PubMed DOI PMC

Kitamura T, Qian BZ, Pollard JW. Immune cell promotion of metastasis. Nat Rev Immunol. 2015;15(2):73–86. doi: 10.1038/nri3789. PubMed DOI PMC

Entenberg D, Rodriguez-Tirado C, Kato Y, Kitamura T, Pollard JW, Condeelis J. In vivo subcellular resolution optical imaging in the lung reveals early metastatic proliferation and motility. Intravital. 2015;4(3):e1086613. PubMed PMC

Kitamura T, Doughty-Shenton D, Cassetta L, Fragkogianni S, Brownlie D, Kato Y, Carragher N, Pollard JW. Monocytes differentiate to immune suppressive precursors of metastasis-associated macrophages in mouse models of metastatic breast Cancer. Front Immunol. 2017;8:2004. doi: 10.3389/fimmu.2017.02004. PubMed DOI PMC

Curiel TJ, Coukos G, Zou L, Alvarez X, Cheng P, Mottram P, Evdemon-Hogan M, Conejo-Garcia JR, Zhang L, Burow M, et al. Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival. Nat Med. 2004;10(9):942–949. doi: 10.1038/nm1093. PubMed DOI

Gourdin N, Bossennec M, Rodriguez C, Vigano S, Machon C, Jandus C, Bauche D, Faget J, Durand I, Chopin N, et al. Autocrine adenosine regulates tumor polyfunctional CD73+CD4+ effector T cells devoid of immune checkpoints. Cancer Res. 2018;78(13):3604–18. PubMed

Coffelt SB, Wellenstein MD, de Visser KE. Neutrophils in cancer: neutral no more. Nat Rev Cancer. 2016;16(7):431–446. doi: 10.1038/nrc.2016.52. PubMed DOI

Coffelt SB, Kersten K, Doornebal CW, Weiden J, Vrijland K, Hau CS, Verstegen NJM, Ciampricotti M, Hawinkels L, Jonkers J, et al. IL-17-producing gammadelta T cells and neutrophils conspire to promote breast cancer metastasis. Nature. 2015;522(7556):345–348. doi: 10.1038/nature14282. PubMed DOI PMC

Kersten K, Coffelt SB, Hoogstraat M, Verstegen NJM, Vrijland K, Ciampricotti M, Doornebal CW, Hau CS, Wellenstein MD, Salvagno C, et al. Mammary tumor-derived CCL2 enhances pro-metastatic systemic inflammation through upregulation of IL1beta in tumor-associated macrophages. Oncoimmunology. 2017;6(8):e1334744. doi: 10.1080/2162402X.2017.1334744. PubMed DOI PMC

Yang N, Williams J, Pekovic-Vaughan V, Wang P, Olabi S, McConnell J, Gossan N, Hughes A, Cheung J, Streuli CH, et al. Cellular mechano-environment regulates the mammary circadian clock. Nat Commun. 2017;8:14287. doi: 10.1038/ncomms14287. PubMed DOI PMC

Williams J, Yang N, Wood A, Zindy E, Meng QJ, Streuli CH. Epithelial and stromal circadian clocks are inversely regulated by their mechano-matrix environment. J Cell Sci. 2018;131(5):jcs208223. PubMed PMC

Tian L, Goldstein A, Wang H, Ching Lo H, Sun Kim I, Welte T, Sheng K, Dobrolecki LE, Zhang X, Putluri N, et al. Mutual regulation of tumour vessel normalization and immunostimulatory reprogramming. Nature. 2017;544(7649):250–254. doi: 10.1038/nature21724. PubMed DOI PMC

Kim IS, Zhang XH. One microenvironment does not fit all: heterogeneity beyond cancer cells. Cancer Metastasis Rev. 2016;35(4):601–629. doi: 10.1007/s10555-016-9643-z. PubMed DOI PMC

Aceto N, Sausgruber N, Brinkhaus H, Gaidatzis D, Martiny-Baron G, Mazzarol G, Confalonieri S, Quarto M, Hu G, Balwierz PJ, et al. Tyrosine phosphatase SHP2 promotes breast cancer progression and maintains tumor-initiating cells via activation of key transcription factors and a positive feedback signaling loop. Nat Med. 2012;18(4):529–537. doi: 10.1038/nm.2645. PubMed DOI

Sausgruber N, Coissieux MM, Britschgi A, Wyckoff J, Aceto N, Leroy C, Stadler MB, Voshol H, Bonenfant D, Bentires-Alj M. Tyrosine phosphatase SHP2 increases cell motility in triple-negative breast cancer through the activation of SRC-family kinases. Oncogene. 2015;34(17):2272–2278. doi: 10.1038/onc.2014.170. PubMed DOI

Bonapace L, Coissieux MM, Wyckoff J, Mertz KD, Varga Z, Junt T, Bentires-Alj M. Cessation of CCL2 inhibition accelerates breast cancer metastasis by promoting angiogenesis. Nature. 2014;515(7525):130–133. doi: 10.1038/nature13862. PubMed DOI

The Eleventh ENBDC Workshop: Advances in Technology Help to Unveil Mechanisms of Mammary Gland Development and Cancerogenesis