Calprotectin and calgranulin C serum levels in bacterial sepsis
Language English Country United States Media print-electronic
Document type Journal Article
PubMed
30420210
DOI
10.1016/j.diagmicrobio.2018.10.006
PII: S0732-8893(18)30480-2
Knihovny.cz E-resources
- Keywords
- Calgranulin C, Calprotectin, Neutrophil-lymphocyte count ratio, Procalcitonin, Sepsis, White blood cell count,
- MeSH
- Bacterial Infections blood diagnosis MeSH
- Biomarkers blood MeSH
- C-Reactive Protein analysis MeSH
- Adult MeSH
- Kinetics MeSH
- Leukocyte L1 Antigen Complex blood MeSH
- Middle Aged MeSH
- Humans MeSH
- Neutrophils cytology MeSH
- Leukocyte Count MeSH
- Lymphocyte Count MeSH
- S100A12 Protein blood MeSH
- Aged MeSH
- Sensitivity and Specificity MeSH
- Sepsis blood diagnosis MeSH
- Virus Diseases blood diagnosis MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Biomarkers MeSH
- C-Reactive Protein MeSH
- Leukocyte L1 Antigen Complex MeSH
- S100A12 Protein MeSH
- S100A12 protein, human MeSH Browser
The aim of this study was to evaluate the serum levels of calprotectin and calgranulin C and routine biomarkers in patients with bacterial sepsis (BS). The initial serum concentrations of calprotectin and calgranulin C were significantly higher in patients with BS (n = 66) than in those with viral infections (n = 24) and the healthy controls (n = 26); the level of calprotectin was found to be the best predictor of BS, followed by the neutrophil-lymphocyte count ratio (NLCR) and the level of procalcitonin (PCT). The white blood cell (WBC) count and the NLCR rapidly returned to normal levels, whereas PCT levels normalized later and the increased levels of calprotectin, calgranulin C, and C-reactive protein persisted until the end of follow-up. Our results suggest that the serum levels of calprotectin are a reliable biomarker of BS and that the WBC count and the NLCR are rapid predictors of the efficacy of antimicrobial therapy.
References provided by Crossref.org
