A study on molecular mechanisms of adiposis induced by long-term treatment of high-fat and high-sucrose in C57BL/6J mice
Jazyk angličtina Země Česko Médium print-electronic
Typ dokumentu časopisecké články
PubMed
30433796
DOI
10.33549/physiolres.933830
PII: 933830
Knihovny.cz E-zdroje
- MeSH
- adipozita fyziologie MeSH
- časové faktory MeSH
- dieta s vysokým obsahem tuků škodlivé účinky trendy MeSH
- DNA-(cytosin-5)-methyltransferasa 1 metabolismus MeSH
- játra metabolismus patologie MeSH
- konzumní sacharóza škodlivé účinky MeSH
- leptin metabolismus MeSH
- myši inbrední C57BL MeSH
- myši MeSH
- přenašeč glukosy typ 4 metabolismus MeSH
- tuková tkáň metabolismus patologie MeSH
- zvířata MeSH
- Check Tag
- mužské pohlaví MeSH
- myši MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- DNA-(cytosin-5)-methyltransferasa 1 MeSH
- Dnmt1 protein, mouse MeSH Prohlížeč
- konzumní sacharóza MeSH
- leptin MeSH
- přenašeč glukosy typ 4 MeSH
- Slc2a4 protein, mouse MeSH Prohlížeč
Adiposis is reputed as a twin disease of type 2 diabetes and greatly harmful to human health. In order to understand the molecular mechanisms of adiposis, the changes of physiological, pathological, epigenetic and correlative gene expression were investigated during the adiposis development of C57BL/6J mice induced by long time (9 months) high-fat and high-sucrose diet (HFSD) sustainably. The results showed that mRNA transcription level of the Leptin, Glut4 and Glut2 genes have been obviously changed, which exhibit a negative correlation with methylation on their promoter DNA. The results also revealed that HFSD induced higher level of DNA methyltransferase 1 (DNMT1) in fat tissue might play important role in regulating the changes of methylation pattern on Glut4 and Leptin genes, and which might be one of the molecular mechanisms for the adiposis development.
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