Although interest in several areas of cephalopod research has emerged over the last decades (e.g., neurobiology, aquaculture, genetics, and welfare), especially following their 2010 inclusion in the EU Directive on the use of animals for experimental purposes, knowledge regarding the parasites of cephalopods is lacking. Cephalopods can be intermediate, paratenic, or definitive hosts to a range of parasites with a wide variety of life cycle strategies. Here, we briefly review the current knowledge in cephalopod parasitological research, summarizing the main parasite groups that affect these animals. We also emphasize some topics that, in our view, should be addressed in future research, including: (i) better understanding of life cycles and transmission pathways of common cephalopod parasites; (ii) improve knowledge of all phases of the life cycle (i.e., paralarvae, juveniles, adults and senescent animals) and on species from polar deep sea regions; (iii) exploration of the potential of using cephalopod-parasite specificity to assess population boundaries of both, hosts and parasites; (iv) risk evaluation of the potential of standard aquacultural practices to result in parasite outbreaks; (v) evaluation and description of the physiological and behavioral effects of parasites on their cephalopod hosts; (vi) standardization of the methods for accurate parasite sampling and identification; (vii) implementation of the latest molecular methods to facilitate and enable research in above mentioned areas; (viii) sharing of information and samples among researchers and aquaculturists. In our view, addressing these topics would allow us to better understand complex host-parasite interactions, yield insights into cephalopod life history, and help improve the rearing and welfare of these animals in captivity.

Association for Cephalopod Research Naples Italy

Department of Botany and Zoology Faculty of Science Masaryk University Brno Czechia

Department of Parasitology Faculty of Science University of South Bohemia České Budějovice Czechia

Dipartimento di Scienze e Tecnologie Università degli Studi del Sannio Benevento Italy

Institute of Parasitology Biology Centre Academy of Sciences of the Czech Republic České Budějovice Czechia

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Abollo E., Gestal C., López A., González A. F., Guerra A., Pascual S. (1998). Squid as trophic bridges for parasite flow within marine ecosystems: the case of DOI

Abollo E., Gestal C., Pascual S. (2001). PubMed DOI

Audicana M. T., Ansotegui I. J., Corres L. F., Kennedy M. W. (2002). Anisakis simplex: dangerous-dead and alive? PubMed DOI

Aznar F. J., Agustí C., Littlewood D. T. J., Raga J. A., Olson P. D. (2007). Insight into the role of cetaceans in the life cycle of the tetraphyllideans (Platyhelminthes: Cestoda). PubMed DOI

Bao M., Pierce G. J., Pascual S., González-Muñoz M., Mattiucci S., Mladineo I., et al. (2017). Assessing the risk of an emerging zoonosis of worldwide concern: anisakiasis. PubMed DOI PMC

Barber I. (2007). Parasites, behaviour and welfare in fish. DOI

Bogolepova-Dobrokhotova I. I. (1953).

Bogolepova-Dobrokhotova I. I. (1960). Dicyemidae of the far-eastern seas. I. New species of the genus Dicyema.

Bogolepova-Dobrokhotova I. I. (1962). Dicyemidae of the far-eastern seas. II. New species of the genus Dicyemennea.

Bychowsky B. E. (1961).

Castellanos-Martínez S., Arteta D., Catarino S., Gestal C. (2014a). De novo transcriptome sequencing of the PubMed DOI PMC

Castellanos-Martínez S., Diz A. P., Álvarez-Chaver P., Gestal C. (2014b). Proteomic characterization of the hemolymph of PubMed DOI

Castellanos-Martínez S., Gestal C. (2013). Pathogens and immune response of cephalopods. DOI

Castellanos-Martínez S., Pérez-Losada M., Gestal C. (2013). Molecular phylogenetic analysis of the coccidian cephalopod parasites PubMed DOI

Catalano S. R. (2012). A review of the families, genera and species of dicyemida van beneden, 1876. DOI

Catalano S. R., Whittington I. D., Donnellan S. C., Gillanders B. M. (2013). Using the giant Australian cuttlefish ( PubMed DOI

Catalano S. R., Whittington I. D., Donnellan S. C., Gillanders B. M. (2014a). Dicyemid fauna composition and infection patterns in relation to cephalopod host biology and ecology. PubMed DOI

Catalano S. R., Whittington I. D., Donnellan S. C., Gillanders B. M. (2014b). Parasites as biological tags to assess host population structure: guidelines, recent genetic advances and comments on a holistic approach. PubMed DOI PMC

Cawthorn R. J., Lynn D. H., Despres B., MacMillan R., Maloney R., Loughlin M., et al. (1996). Description of Anophryoides haemophila n. sp. (Scuticociliatida: Orchitophryidae), a pathogen of American lobsters DOI

Davey J. W., Blaxter M. L. (2010). RADSeq: next-generation population genetics. PubMed DOI PMC

Derevnina L., Petre B., Kellner R., Dagdas Y. F., Sarowar M. N., Giannakopoulou A., et al. (2016). Emerging oomycete threats to plants and animals. PubMed DOI PMC

Diamant A. (1997). Fish-to-fish transmission of a marine myxosporean. DOI

Dobell C. C. (1925). The life history and chromosome cycle of DOI

Dollfus R. P. (1958). Copepodes, isopodes et helminths parasites de Cephalopodes de la Mediterranee et de l’Atlantique Europeen.

Dyková I., Lom J. (2004). Advances in the knowledge of amphizoic amoebae infecting fish. PubMed DOI

Furuya H. (2007). Redescription of two dicyemennea (Phylum: Dicyemida) From PubMed DOI

Furuya H., Ota M., Kimura R., Tsuneki K. (2004). Renal organs of cephalopods: a habitat for dicyemids and chromidinids. PubMed DOI

Gerdol M., Gomez-Chiarri M., Castillo M. G., Figueras A., Fiorito G., Moreira R., et al. (2018). “Immunity in molluscs: recognition and effector mechanisms, with a focus on bivalvia,” in

Gestal C., Abollo E., Pascual S. (2002a). Observations on associated histopathology with PubMed DOI

Gestal C., De La Cadena M. P., Pascual S. (2002b). Malabsorption syndrome observed in the common octopus PubMed DOI

Gestal C., Guerra A., Pascual S. (2007). DOI

Gestal C., Pascual S., Corral L., Azevedo C. (1999). Ultrastructural aspects of the sporogony of DOI

Gestal C., Pascual S., Hochberg F. G. (2010). PubMed DOI

González A. F., Pascual S., Gestal C., Abollo E., Guerra A. (2003). What makes a cephalopod a suitable host for parasite? The case of Galician waters. DOI

Hanlon R. T., Forsythe J. W. (1990a). “Diseases of mollusca: cephalopoda: diseases caused by microorganisms,” in

Hanlon R. T., Forsythe J. W. (1990b). “Diseases of mollusca: cephalopoda: structural abnormalitie and neoplasia,” in

Heil M. (2016). Host manipulation by parasites: cases, patterns, and remaining doubts. DOI

Hochberg F. G. (1990). “Diseases of mollusca: cephalopoda: diseases caused by protistans and metazoans,” in

Humes A. G., Voight J. R. (1997). Cholidya polypi (copepoda: Harpacticoida: Tisbidae), a parasite of deep-sea octopuses in the north atlantic and northeastern pacific. DOI

Johnson S. C., Bravo S., Nagasawa K., Kabata Z., Hwang J., Ho J., et al. (2004). A review of the impact of parasitic copepods on marine aquaculture.

Katayama T., Wada H., Furuya H., Satoh N., Yamamoto M. (1995). Phylogenetic position of the dicyemid Mesozoa inferred from 18S rDNA sequences. PubMed DOI

Kinne O. (1990).

Klotz D., Hirzmann J., Bauer C., Schöne J., Iseringhausen M., Wohlsein P., et al. (2018). Subcutaneous merocercoids of Clistobothrium sp. in two Cape fur seals ( PubMed DOI PMC

Kopečná J., Jirku M., Oborník M., Tokarev Y. S., Lukeš J., Modrý D. (2006). Phylogenetic analysis of coccidian parasites from invertebrates: search for missing links. PubMed DOI

Kuris A. M., Lafferty K. D., Sokolow S. H. (2014). Sapronosis: a distinctive type of infectious agent. PubMed DOI

Lafferty K. D. (1999). The evolution of trophic transmission. PubMed DOI

Lafferty K. D., Morris A. K. (1996). Altered behavior of parasitized killifish increases susceptibility to predation by bird final hosts. DOI

Llewellyn J. (1984). The biology of DOI

Lom J., Dyková I. (1992).

López-González P. J., Bresciani J., Huys R., González A. F., Guerra A., Pascual S. (2000). Description of Genesis vulcanoctopusi gen. et sp. nov. (Copepoda: Tisbidae) parasitic on a hydrothermal vent octopod and a reinterpretation of the life cycle of cholidyinid harpacticoids.

MacKenzie K. (1999). Parasites as biological tags in population studies of marine fish. DOI

Mattiucci S., Cimmaruta R., Cipriani P., Abaunza P., Bellisario B., Nascetti G. (2015). Integrating PubMed DOI

Mattiucci S., Cipriani P., Levsen A., Paoletti M., Nascetti G. (2018). Molecular epidemiology of PubMed DOI

Mattiucci S., D’Amelio S. (2014). “Anisakiasis,” in DOI

Mattiucci S., Fazii P., De Rosa A., Paoletti M., Megna A. S., Glielmo A., et al. (2013). Anisakiasis and gastroallergic reactions associated with PubMed DOI PMC

Mladineo I., Bočina I. (2007). Extraintestinal gamogony of PubMed DOI

Moran J. D. W., Whitaker D. J., Kent M. L. (1999). A review of the myxosporean genus Kudoa Meglitsch, 1947, and its impact on the international aquaculture industry and commercial fisheries. DOI

Nigmatullin C. M., Shchetinnikov A. S., Shukhgalter O. A. (2009). On feeding and helminth fauna of neon flying squid DOI

Nouvel H. (1947). Les dicyémides 1er partie: systématique, générations vermiformes, infusorigène et sexualité. PubMed

Nouvel H. (1948). Les dicyemides 2em partie: infusoriforme, teratologie, specificite du parasitisime, affinites. PubMed

Overstreet R. M. (1973). Parasites of some penaeid shrimps with emphasis on reared hosts. DOI

Overstreet R. M., Hochberg F. G. (1975). Digenetic trematodes in cephalopods. DOI

Palombi A. (1949). I trematodi d’ltalia, Parte I. Trematodi monogenetici.

Pascual S., Gestal C., Estévez J. M., Rodríguez H., Soto M., Abollo E., et al. (1996). Parasites in commercially-exploited cephalopods (Mollusca, Cephalopoda) in Spain: an updated perspective. DOI

Pascual S., González A., Arias C., Guerra A. (1995). Helminth infection in the short-finned squid PubMed DOI

Pascual S., González A., Guerra A. (2007). Parasites and cephalopod fisheries uncertainty: towards a waterfall understanding. DOI

Pascual S., González A. F., Guerra A. (2010). Coccidiosis during octopus senescence: preparing for parasite outbreak. DOI

Pascual S., Hochberg F. G. (1996). Marine parasites as biological tags of cephalopod hosts. PubMed DOI

Pernice M., Boucher-Rodoni R. (2012). Occurrence of a specific dual symbiosis in the excretory organ of geographically distant Nautiloids populations. PubMed DOI

Pernice M., Wetzel S., Gros O., Boucher-Rodoni R., Dubilier N. (2007). Enigmatic dual symbiosis in the excretory organ of PubMed DOI PMC

Petrić M., Mladineo I., Šifner S. K. (2011). Insight into the short-finned squid PubMed DOI

Poulin R., Blasco-Costa I., Randhawa H. S. (2016). Integrating parasitology and marine ecology: seven challenges towards greater synergy. DOI

Poulin R., Morand S. (2000). The diversity of parasites. PubMed DOI

Poulin R., Mouillot D. (2003). Parasite specialization from a phylogenetic perspective: a new index of host specificity. PubMed DOI

Randhawa H. S., Brickle P. (2011). Larval parasite gene sequence data reveal cryptic trophic links in life cycles of porbeagle shark tapeworms. DOI

Ridley R. K. (1968). Electron microscopic studies on Dicyemid mesozoa. I. Vermiform Stages. DOI

Riginos C., Crandall E. D., LIggins L., Bongaerts P., Treml E. A. (2016). Navigating the currents of seascape genomics: how spatial analyses can augment population genomic studies. PubMed DOI PMC

Ruby E. G. (1999). The euprymna scolopes- PubMed

Shukhgalter O. A., Nigmatullin C. M. (2001). Parasitic helminths of jumbo squid DOI

Smith J. W., Wootten R. (1978). PubMed DOI

Smith J. W., Wootten R. (1984). “Anisakis larvae (herringworm) (nematoda) in fish. Parasitose des poissons par les larves du nématode

Souidenne D., Florent I., Dellinger M., Justine J., Romdhane M. S., Furuya H., et al. (2016). Diversity of apostome ciliates, PubMed DOI PMC

Sproston N. G. (1946). A synopsis of the monogenetic trematodes.

Sykes A. V., Almansa E., Cooke G. M., Ponte G., Andrews P. L. (2017). The digestive tract of cephalopods: a neglected topic of relevance to animal welfare in the laboratory and aquaculture. PubMed DOI PMC

Sykes A. V., Gestal C. (2014). “Welfare and diseases under culture conditions,” in DOI

Tao Z., Liu L., Chen X., Zhou S., Wang G. (2016). First isolation of PubMed DOI

Tedesco P., Gestal C., Begić K., Mladineo I., Castellanos-Martínez S., Catanese G., et al. (2017). Morphological and molecular characterization of aggregata spp. Frenzel 1885 (Apicomplexa: Aggregatidae) in PubMed DOI

Thompson S. N., Kavaliers M. (1994). Physiological bases for parasite-induced alterations of host behaviour. PubMed DOI

Thoney D. A., Hargis W. J., Jr. (1991). Monogenea (Platyhelminthes) as hazards for fish in confinement. DOI

Van Beneden M. E. (1876). Recherches sur le Dicyemides, survivants actuels d’un embranchement des Mésozoaires.

Vecchione M. (1987). “Juvenile ecology,” in

Vidal E. A. G., Haimovici M. (1999). Digestive tract parasites in rhynchoteuthion squid paralarvae, particularly in

Yokoyama H., Masuda K. (2001).