The prognostic value of ultra low-dose thallium myocardial perfusion protocol using CZT SPECT
Language English Country United States Media print-electronic
Document type Journal Article
Grant support
LQ1605 from the National Program of Sustainability II (MEYS CR)
Ministerstvo Školství, Mládeže a Tělovýchovy
PubMed
30680654
DOI
10.1007/s10554-019-01535-7
PII: 10.1007/s10554-019-01535-7
Knihovny.cz E-resources
- Keywords
- CZT, Low-dose, Myocardial perfusion, Prognostic value, SPECT, Thallium,
- MeSH
- Time Factors MeSH
- Radiation Dosage * MeSH
- Equipment Design MeSH
- Gamma Cameras * MeSH
- Myocardial Ischemia diagnostic imaging mortality physiopathology therapy MeSH
- Tomography, Emission-Computed, Single-Photon adverse effects instrumentation methods MeSH
- Cadmium * MeSH
- Coronary Circulation * MeSH
- Middle Aged MeSH
- Humans MeSH
- Pilot Projects MeSH
- Predictive Value of Tests MeSH
- Prognosis MeSH
- Disease Progression MeSH
- Purines administration & dosage MeSH
- Pyrazoles administration & dosage MeSH
- Radiation Exposure adverse effects prevention & control MeSH
- Radiopharmaceuticals administration & dosage adverse effects MeSH
- Thallium Radioisotopes administration & dosage adverse effects MeSH
- Reproducibility of Results MeSH
- Aged MeSH
- Tellurium * MeSH
- Vasodilator Agents administration & dosage MeSH
- Exercise Test MeSH
- Zinc * MeSH
- Myocardial Perfusion Imaging adverse effects instrumentation methods MeSH
- Check Tag
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- CdZnTe MeSH Browser
- Cadmium * MeSH
- Purines MeSH
- Pyrazoles MeSH
- Radiopharmaceuticals MeSH
- Thallium Radioisotopes MeSH
- regadenoson MeSH Browser
- Tellurium * MeSH
- Thallium-201 MeSH Browser
- Vasodilator Agents MeSH
- Zinc * MeSH
The purpose of this study was to assess the prognostic value of ultra-low dose thallium myocardial perfusion imaging. Three hundred and sixty-six patients (245 men) underwent ultra-low dose stress-redistribution imaging on CZT SPECT camera GE Discovery NM 530c. The stress test was performed by bicycle ergometry or regadenoson injection. The activity of 0.5 MBq (0.014 mCi) Tl-201 chloride per kilogram of body weight was administered. The stress images were acquired immediately and redistribution images were taken after 3 h. Patient follow-up was focused on combined end-point (death, myocardial infarction, unstable angina, revascularization and hospitalization for heart failure). Data analysis was performed from hospital database, with a mean period 23 months. Patients with revascularization within 1 month after SPECT was excluded as revascularization for diagnosis. Ischaemia on SPECT was found in 72 patients, 294 patients were without ischaemia. In patients with ischaemia there were 21 (29.2%) subjects with cardiac events, and 23 (7.9%) in patients without ischaemia (HR 4.15, 95% CI 2.30-7.51, p < 0.0001). Ultra-low dose thallium perfusion imaging using CZT camera provides very good prognostic results in assessment of myocardial ischaemia.
Department of Nuclear Medicine Masaryk Memorial Cancer Center Brno Czech Republic
Department of Nuclear Medicine University Hospital Olomouc Palacky University Olomouc Czech Republic
Department of Pathological Physiology Faculty of Medicine Masaryk University Brno Czech Republic
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