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Diagnostická úskalí celiakie
[Diagnostic pitfalls of celiac disease]

. 2019 Winter ; 65 (1) : 24-29.

Language Czech Country Czech Republic Media print

Document type Journal Article

Links

PubMed 30823834
PII: 107900

Celiac disease is a very common autoimmune disorder caused by the ingestion of dietary gluten products in genetically susceptible persons. Its global prevalence is estimated around 1 %. However, the most cases are not diagnosed. Clinical presentation is widely variable with the involvement of various human systems. Besides a clinical picture (that is often non characteristic), the diagnosis is based on positivity of serological testing (tissue transglutaminase autoantibodies) and histological evaluation of small intestinal mucosa. The article presents a rational diagnostic approach to celiac disease. Key words: celiac disease - Marsh classification - tissue transglutaminase autoantibodies - villous atrophy.

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