Diagnostická úskalí celiakie
[Diagnostic pitfalls of celiac disease]
Language Czech Country Czech Republic Media print
Document type Journal Article
PubMed
30823834
PII: 107900
- Keywords
- celiac disease - Marsh classification - tissue transglutaminase autoantibodies - villous atrophy,
- MeSH
- Autoantibodies MeSH
- Celiac Disease * diagnosis immunology MeSH
- Duodenum MeSH
- Glutens MeSH
- Humans MeSH
- Intestinal Mucosa MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Autoantibodies MeSH
- Glutens MeSH
Celiac disease is a very common autoimmune disorder caused by the ingestion of dietary gluten products in genetically susceptible persons. Its global prevalence is estimated around 1 %. However, the most cases are not diagnosed. Clinical presentation is widely variable with the involvement of various human systems. Besides a clinical picture (that is often non characteristic), the diagnosis is based on positivity of serological testing (tissue transglutaminase autoantibodies) and histological evaluation of small intestinal mucosa. The article presents a rational diagnostic approach to celiac disease. Key words: celiac disease - Marsh classification - tissue transglutaminase autoantibodies - villous atrophy.