Dynamic creep properties of a novel nanofiber hernia mesh in abdominal wall repair
Language English Country France Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
Grant support
NV17-32285A
Ministerstvo Zdravotnictví Ceské Republiky - International
PubMed
30953212
DOI
10.1007/s10029-019-01940-w
PII: 10.1007/s10029-019-01940-w
Knihovny.cz E-resources
- Keywords
- Dynamic properties, Hernia, Nanofibres, PCL,
- MeSH
- Hernia, Abdominal * etiology surgery MeSH
- Abdominoplasty instrumentation methods MeSH
- Surgical Mesh * MeSH
- Incisional Hernia * etiology surgery MeSH
- Rabbits MeSH
- Disease Models, Animal MeSH
- Nanofibers therapeutic use MeSH
- Herniorrhaphy instrumentation methods MeSH
- Tensile Strength MeSH
- Polypropylenes therapeutic use MeSH
- Elasticity MeSH
- Materials Testing MeSH
- Animals MeSH
- Check Tag
- Rabbits MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Polypropylenes MeSH
PURPOSE: Incisional hernia is the most common complication following abdominal surgery. While mesh repair is common, none of the current meshes mimic the physiology of the abdominal wall. This study compares suture only repair with polypropylene mesh and a prototype of a novel implant (poly-epsilon-caprolactone nanofibers) and their influence on the physiology of an abdominal wall in an animal model. METHODS: 27 Chinchilla rabbits were divided into six groups based on the type of the implant. Midline abdominal incision was repaired using one of the compared materials with suture alone serving as the control. 6 weeks post-surgery animals were killed and their explanted abdominal wall subjected to biomechanical testing. RESULTS: Both-hysteresis and maximum strength curves showed high elasticity and strength in groups where the novel implant was used. Polypropylene mesh proved as stiff and fragile compared to other groups. CONCLUSION: Poly-epsilon-caprolactone nanofiber scaffold is able to improve the dynamic properties of healing fascia with no loss of maximum tensile strength when compared to polypropylene mesh in an animal model.
2nd Medical Faculty at Charles University 5 uvalu 84 15006 Prague Czech Republic
3rd Department of Surgery Motol University Hospital 5 uvalu 84 15006 Prague Czech Republic
Royal Infirmary of Edinburgh Little France Crescent Edinburgh EH16 4SA UK
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