AIMS: The European Society of Cardiology (ESC) EURObservational Research Programme (EORP) European Endocarditis (EURO-ENDO) registry aims to study the care and outcomes of patients diagnosed with infective endocarditis (IE) and compare findings with recommendations from the 2015 ESC Clinical Practice Guidelines for the management of IE and data from the 2001 Euro Heart Survey. METHODS AND RESULTS: Patients (n = 3116) aged over 18 years with a diagnosis of IE based on the ESC 2015 IE diagnostic criteria were prospectively identified between 1 January 2016 and 31 March 2018. Individual patient data were collected across 156 centres and 40 countries. The primary endpoint is all-cause mortality in hospital and at 1 year. Secondary endpoints are 1-year morbidity (all-cause hospitalization, any cardiac surgery, and IE relapse), the clinical, epidemiological, microbiological, and therapeutic characteristics of patients, the number and timing of non-invasive imaging techniques, and adherence to recommendations as stated in the 2015 ESC Clinical Practice Guidelines for the management of IE. CONCLUSION: EURO-ENDO is an international registry of care and outcomes of patients hospitalized with IE which will provide insights into the contemporary profile and management of patients with this challenging disease.

Aix Marseille Univ IRD APHM MEPHI IHU Méditerranée Infection Marseille France

Cairo University Hospitals Cairo Egypt

Cardiology Department APHM La Timone Hospital Boulevard Jean Moulin Marseille France

Centrum voor Hart en Vaatziekten Unversitair Ziekenhuis Brussel Laarbeeklaan 101 Brussel Belgium

Department of Cardiology Heart Valve Clinic University of Liège Hospital GIGA Cardiovascular Sciences CHU Sart Tilman Avenue de l'hôpital n1 ège Belgium

Department of Cardiology Hospital Universitari Vall d'Hebron Barcelona Spain

Department of cardiology SOS Endocardites Henri Mondor Hospital Creteil France

Department of Cardiology University Hospital Vall d'Hebron Barcelona Spain

Department of Cardiology University of Medicine and Pharmacy Carol Davila Euroecolab Emergency Institute of Cardiovascular Diseases Prof Dr C C Iliescu Sos Fundeni 258 Sector 2 Bucharest Romania

Department of Nuclear Medicine University of Pisa Pisa Italy

EURObservational Research Programme European Society of Cardiology France ANMCO Research Center Florence Italy

EURObservational Research programme European Society of Cardiology Sophia Antipolis France

Gruppo Villa Maria Care and Research Anthea Hospital Bari Italy

Guy's and St Thomas' London UK

Hopital Bichat Paris France

Institute for Clinical and Experimental Medicine Prague Czech Republic

Leeds Institute of Cardiovascular and Metabolic Medicine University of Leeds Leeds UK

National Institute of Cardiovascular Disease Karachi Pakistan

Rajaie Cardiovascular Medical and Research Center Echocardiography Research Center Iran University of Medical Sciences Tehran Iran

Universitat Autònoma de Barcelona Barcelona Spain

University Hospital San Giovanni di Dio e Ruggi d'Aragona Salerno Italy

University of Groningen University Medical Center Groningen Medical Imaging Center Groningen The Netherlands

University of Rennes CHU Rennes Inserm LTSI UMR 1099 Rennes France

Eur Heart J Qual Care Clin Outcomes. 2019 Jul 1;5(3):185-186. doi: 10.1093/ehjqcco/qcz028. PubMed

Eur Heart J Qual Care Clin Outcomes. 2020 Jan 1;6(1):91. doi: 10.1093/ehjqcco/qcz060. PubMed

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Characteristics, management, and outcomes of patients with left-sided infective endocarditis complicated by heart failure: a substudy of the ESC-EORP EURO-ENDO (European infective endocarditis) registry