Cyclodextrins as Chiral Selectors in Capillary Electrophoresis Enantioseparations
Language English Country United States Media print
Document type Journal Article
- Keywords
- Capillary electrophoresis, Chiral separation, Cyclodextrin, Enantiomer migration order, Enantioseparation,
- MeSH
- Cyclodextrins chemistry MeSH
- Electrophoresis, Capillary methods MeSH
- Hydrogen-Ion Concentration MeSH
- Ofloxacin chemistry isolation & purification MeSH
- Silicon Dioxide chemistry MeSH
- Stereoisomerism MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Cyclodextrins MeSH
- Ofloxacin MeSH
- Silicon Dioxide MeSH
Due to their structural variability and their commercial availability, cyclodextrins are the most frequently used chiral selectors in capillary electrophoresis. A variety of migration modes can be realized depending on the characteristics of the cyclodextrins and the analytes. The basic considerations regarding the development of a chiral CE method employing cyclodextrins as chiral selectors are briefly discussed. The presented examples illustrate the separation modes of an acidic and a basic analyte with native and charged cyclodextrin derivatives as a function of the pH of the background electrolyte and the concentration of the cyclodextrin.
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