Hippocampal high frequency oscillations in unilateral and bilateral mesial temporal lobe epilepsy
Language English Country Netherlands Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
31100580
DOI
10.1016/j.clinph.2019.03.026
PII: S1388-2457(19)30120-8
Knihovny.cz E-resources
- Keywords
- Bitemporal epilepsy, High frequency oscillations, Hippocampal sclerosis, Hippocampus, Temporal lobe epilepsy,
- MeSH
- Amygdala physiopathology MeSH
- Adult MeSH
- Electroencephalography methods MeSH
- Epilepsy, Temporal Lobe pathology physiopathology MeSH
- Hippocampus pathology physiopathology MeSH
- Electrodes, Implanted MeSH
- Middle Aged MeSH
- Humans MeSH
- Young Adult MeSH
- Retrospective Studies MeSH
- Temporal Lobe physiopathology MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Young Adult MeSH
- Male MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
OBJECTIVE: The main aim of this study was to investigate the potential differences in terms of interictal high frequency oscillations (HFOs) between both hippocampi in unilateral (U-MTLE) and bilateral mesial temporal lobe epilepsy (B-MTLE). METHODS: Sixteen patients with MTLE underwent bilateral hippocampal depth electrode implantation as part of epilepsy surgery evaluation. Interictal HFOs were detected automatically. The analyses entail comparisons of the rates and spatial distributions of ripples and fast ripples (FR) in hippocampi and amygdalae, with respect to the eventual finding of hippocampal sclerosis (HS). RESULTS: In U-MTLE, higher ripple and FR rates were found in the hippocampi ipsilateral to the seizure onset than in the contralateral hippocampi. Non-epileptic hippocampi in U-MTLE were distinguished by significantly lower ripple rate than in the remaining analyzed hippocampi. There were not differences between the hippocampi in B-MTLE. In the hippocampi with proven HS, higher FR rates were observed in the ventral than in the dorsal parts. CONCLUSIONS: Non-epileptic hippocampi in U-MTLE demonstrated significantly lower ripple rates than those epileptic in U-MTLE and B-MTLE. SIGNIFICANCE: Low interictal HFO occurrence might be considered as a marker of the non-epileptic hippocampi in MTLE.
References provided by Crossref.org
