Extracellular polysaccharide produced by Chlorella vulgaris - Chemical characterization and anti-asthmatic profile
Jazyk angličtina Země Nizozemsko Médium print-electronic
Typ dokumentu časopisecké články
PubMed
31121228
DOI
10.1016/j.ijbiomac.2019.05.104
PII: S0141-8130(19)32253-6
Knihovny.cz E-zdroje
- Klíčová slova
- Anti-asthmatic effect, Extracellular polysaccharide, Green microalgae,
- MeSH
- alergeny MeSH
- antiastmatika chemie metabolismus farmakologie MeSH
- bronchiální hyperreaktivita farmakoterapie imunologie patofyziologie MeSH
- chemické jevy MeSH
- Chlorella vulgaris metabolismus MeSH
- cytokiny metabolismus MeSH
- extracelulární prostor metabolismus MeSH
- hladké svalstvo účinky léků imunologie metabolismus MeSH
- mediátory zánětu metabolismus MeSH
- modely nemocí na zvířatech MeSH
- morčata MeSH
- polysacharidy biosyntéza chemie farmakologie MeSH
- spektrální analýza MeSH
- zvířata MeSH
- Check Tag
- morčata MeSH
- mužské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- alergeny MeSH
- antiastmatika MeSH
- cytokiny MeSH
- mediátory zánětu MeSH
- polysacharidy MeSH
Microalgae are the lowest plant organisms producing a wide range of metabolites that make them interesting organisms for industrial applications. Cultivation of green microalgal species Chlorella vulgaris resulted a significant production of extracellular polysaccharide (EPS). Preliminary chemico-spectroscopic studies on EPS revealed its molecular profile, a complex primary structure consisting of six monosaccharide units occurring in both furano and pyrano forms, a high sugar binding variability and the presence of partially methylated derivatives of some sugar constituents. Biological activity tests showed that EPS caused significant bronchodilatory, anti-inflammatory and antitussive effects in test animals. Chlorella EPS appears to be a promising agent for the prevention of chronic airway inflammation, which is the basic pathogenic mechanism of many respiratory diseases, including bronchial asthma.
Biomedical Center Jessenius Faculty of Medicine 03601 Martin Slovakia
Institute of Microbiology Academy of Sciences of the Czech Republic Treboň Czechia
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