Disorganization of retinal inner layers correlates with ellipsoid zone disruption and retinal nerve fiber layer thinning in diabetic retinopathy
Jazyk angličtina Země Spojené státy americké Médium print-electronic
Typ dokumentu časopisecké články
PubMed
31186163
DOI
10.1016/j.jdiacomp.2019.05.006
PII: S1056-8727(19)30249-1
Knihovny.cz E-zdroje
- Klíčová slova
- Diabetic retinopathy, Disorganization of inner retinal layer (DRIL), Imaging biomarkers, Macular thickness parameters, Retinal nerve fiber layer (RNFL) thickness, Spectral domain optical coherence tomography (SD-OCT),
- MeSH
- diabetes mellitus 2. typu komplikace MeSH
- diabetická retinopatie patologie patofyziologie MeSH
- lidé středního věku MeSH
- lidé MeSH
- macula lutea patologie MeSH
- nervová vlákna fyziologie MeSH
- optická koherentní tomografie MeSH
- průřezové studie MeSH
- retina patologie patofyziologie MeSH
- zraková ostrost MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
PURPOSE: To study the correlation between disorganization of inner retinal layer (DRIL) and macular thickness parameters, ellipsoid zone (EZ) disruption and retinal nerve fiber layer (RNFL) thickness on spectral domain optical coherence tomography (SD-OCT) in diabetic retinopathy (DR), for the first time. METHODS: A tertiary care center-based cross-sectional study was undertaken. One hundred and four consecutive study subjects of type 2 diabetes mellitus were included: diabetes mellitus with no retinopathy (No DR) (n = 26); non-proliferative DR (NPDR) (n = 26); proliferative DR (PDR) (n = 26) and healthy controls (n = 26). Best Corrected Visual Acuity (BCVA) was measured on the logarithm of the minimum angle of resolution (logMAR) scale. Clinician-friendly, SD-OCT based, grading systems were created for DRIL and EZ disruption, within the macular cube. DRIL was graded as: grade 0, DRIL absent; and grade 1, DRIL present. EZ disruption was graded as; Grade 0: Intact EZ; Grade 1: Focal disruption and Grade 2: Global disruption. Every study subject underwent RNFL thickness analysis. RESULTS: DRIL was significantly associated with increase in severity of DR.Pearson correlation analysis showed significant positive correlation between DRIL and CST CAT and grades of EZ disruption . However, a significant negative correlation was found between DRIL and RNFL thickness . CONCLUSION: Presence of DRIL correlates with severity of DR, EZ disruption and RNFL thinning.
Department of Internal Medicine Brothers of Mercy Hospital Brno Czech Republic
Department of Ophthalmology King George's Medical University Lucknow India
Department of Ophthalmology Queen Elizabeth Hospital University of Adelaide Adelaide Australia
Faculty of Health Science and Social Work Trnava University Trnava Slovakia
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