Vocal cord inflammatory myofibroblastic tumor with mucoid deposits harboring TIMP3-ALK fusion: A potential diagnostic pitfall
Jazyk angličtina Země Austrálie Médium print-electronic
Typ dokumentu kazuistiky, časopisecké články
PubMed
31215130
DOI
10.1111/pin.12796
Knihovny.cz E-zdroje
- Klíčová slova
- anaplastic lymphoma kinase, inflammatory myofibroblastic tumor, liposarcoma, vocal cord polyp,
- MeSH
- anaplastická lymfomová kináza metabolismus MeSH
- dospělí MeSH
- hlasové řasy metabolismus MeSH
- lidé MeSH
- myofibroblasty patologie MeSH
- nádorové biomarkery genetika MeSH
- plazmocelulární granulom diagnóza patologie MeSH
- tkáňový inhibitor metaloproteinasy 3 metabolismus MeSH
- tyrosinkinasové receptory genetika MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- mužské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- kazuistiky MeSH
- Názvy látek
- ALK protein, human MeSH Prohlížeč
- anaplastická lymfomová kináza MeSH
- nádorové biomarkery MeSH
- TIMP3 protein, human MeSH Prohlížeč
- tkáňový inhibitor metaloproteinasy 3 MeSH
- tyrosinkinasové receptory MeSH
A 35-year-old Japanese man who had experienced hoarseness for 10 years presented with a vocal cord lesion. A gross examination revealed a left vocal cord polyp occupying two-thirds of the vocal space. The endoscopically resected lesion contained scattered atypical fibroblastic, stellate, or ganglion-like cells with mucoid stroma. Vacuolated cells were also seen. Lymphoplasmacytic infiltrate was largely undetectable. A vocal cord polyp was first suspected, but well-differentiated liposarcoma and inflammatory myofibroblastic tumor (IMT) were included in the differential diagnoses. The tumor cells were positive for anaplastic lymphoma kinase (ALK), calponin, and vimentin, and negative for other smooth muscle markers by immunohistochemistry. Structures resembling myofibroblasts were not observed by electron microscopy, which confirmed abundant rough endoplasmic reticulum in the tumor cells and accumulated lipid droplets in some tumor cells. ALK gene rearrangement was detected by fluorescence in situ hybridization, and TIMP3-ALK fusion was confirmed by 5' rapid amplification of cDNA ends. We diagnosed the lesion as an IMT, and an ALK-rearranged stellate cell tumor may be postulated. This is the first report of a fusion partner gene of ALK in a case of laryngeal IMT.
Department of Diagnostic Pathology Japanese Red Cross Kochi Hospital Kochi Japan
Department of Otorhinolaryngology Japanese Red Cross Kochi Hospital Kochi Japan
Department of Pathology Kochi Medical School Kochi University Kochi Japan
Division of Pathology Cancer Institute Japanese Foundation for Cancer Research Tokyo Japan
Equipment of Support Planning Office Kochi University Kochi Japan
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