Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-5
Jazyk angličtina Země Švýcarsko Médium electronic
Typ dokumentu úvodníky
PubMed
31262039
PubMed Central
PMC6650823
DOI
10.3390/molecules24132415
PII: molecules24132415
Knihovny.cz E-zdroje
- MeSH
- farmaceutická chemie trendy MeSH
- lidé MeSH
- objevování léků trendy MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- úvodníky MeSH
Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes is a series of Editorials which is published on a biannual basis by the Editorial Board of the Medicinal Chemistry section of the journal Molecules [...].
Department of Agricultural Sciences University of Naples Federico 2 80055 Portici Italy
Department of Pharmacy University of Naples Federico 2 Via Mezzocannone 16 80134 Napoli Italy
Department of Pharmacy University of Pisa Via Bonanno 6 56126 Pisa Italy
Department of Sciences University of Basilicata Viadell'Ateneo Lucano 10 85100 Potenza Italy
Formerly head of the Department of Organic Chemistry University of Mons UMONS 7000 Mons Belgium
ICOA CNRS UMR 7311 Universite d'Orleans Rue de Chartres 45067 Orleans CEDEX 2 France
Pharmaceutical Institute University of Bonn An der Immenburg 4 53115 Bonn Germany
School of Pharmacy Keele University Hornbeam building Staffordshire ST5 5BG UK
Zobrazit více v PubMed
Kalkman D.N., Aquino M., Claessen B.E., Baber U., Guedeney P., Sorrentino S., Vogel B., de Winter R.J., Sweeny J., Kovacic J.C., et al. Residual inflammatory risk and the impact on clinical outcomes in patients after percutaneous coronary interventions. Eur. Heart J. 2018;39:4101–4108. doi: 10.1093/eurheartj/ehy633. PubMed DOI
Hersberger M. Potential role of the lipoxygenase derived lipid mediators in atherosclerosis: Leukotrienes, lipoxins and resolvins. Clin. Chem. Lab. Med. 2010;48:1063–1073. doi: 10.1515/CCLM.2010.212. PubMed DOI
Pettersen D., Broddefalk J., Emtenas H., Hayes M.A., Lemurell M., Swanson M., Ulander J., Whatling C., Amilon C., Ericsson H., et al. Discovery and early clinical development of an inhibitor of 5-lipoxygenase activating protein (AZD5718) for treatment of coronary artery disease. J. Med. Chem. 2019;62:4312–4324. doi: 10.1021/acs.jmedchem.8b02004. PubMed DOI
Sexton T.R., Zhang G., Macaulay T.E., Callahan L.A., Charnigo R., Vsevolozhskaya A., Li Z., Smyth S. Ticagrelor reduces thromboinflammatory markers in patients with pneumonia. JACC Basic Transl. Sci. 2018;3:435–449. doi: 10.1016/j.jacbts.2018.05.005. PubMed DOI PMC
Lancellotti P., Musumeci L., Jacques N., Servais L., Goffin E., Pirotte B., Oury C. Antibacterial activity of ticagrelor in conventional antiplatelet dosages against antibiotic-resistant Gram-positive bacteria. JAMA Cardiol. 2019 May 8; doi: 10.1001/jamacardio.2019.1189. PubMed DOI PMC
Ndagi U., Mhlongo N., Soliman M.E. Metal complexes in cancer therapy – an update from drug design perspective. Drug Des. Dev. Ther. 2017;11:599–616. doi: 10.2147/DDDT.S119488. PubMed DOI PMC
Starha P., Travnicek Z., Dvorak Z. A cytotoxic tantalum(V) half-sandwich complex: A new challenge for metal-based anticancer agents. Chem. Commun. 2018;54:9533–9536. doi: 10.1039/C8CC05223A. PubMed DOI
Travnicek Z., Starha P., Cajan M., Dvorak Z. A half-sandwich TaV dichlorido complex containing an O,N,O′-tridentate Schiff base ligand: Synthesis, crystal structure and in vitro cytotoxicity. Acta Cryst. 2019;C75:248–254. PubMed
Starha P., Travnicek Z., Dvorak Z. Dichloro-complexes of tantalum, method of their preparation and their use in preparation of drugs for cancer treatment. CZ 307 696 B6. 2019 Jan 9;
de Oliveira Pedrosa M., Duarte da Cruz R.M., de Oliveira Viana J., de Moura R.O., Ishiki H.M., Barbosa Filho J.M., Diniz M.F., Scotti M.T., Scotti L., Bezerra Mendonca F.J. Hybrid Compounds as Direct Multitarget Ligands: A Review. Curr. Top. Med. Chem. 2017;17:1044–1079. doi: 10.2174/1568026616666160927160620. PubMed DOI
Thi T.H.N., Thi Y.T., Nguyen L.A., Vo B.N., Ngo Q.A. Design, Synthesis and Biological Activities of New Pyrazole Derivatives Possessing Both Coxib and Combretastatins Pharmacophores. Chem. Biodivers. 2019 Apr 11; doi: 10.1002/cbdv.201900108. PubMed DOI
Lee M.J., Bhattarai D., Yoo J., Miller Z., Park J.E., Lee S., Lee W., Driscoll J.J., Kim K.B. Development of novel epoxyketone-based proteasome inhibitors as a strategy to overcome cancer resistance to carfilzomib and bortezomib. J. Med. Chem. 2019;62:4444–4455. doi: 10.1021/acs.jmedchem.8b01943. PubMed DOI PMC
Koldysheva E., Men’shchikova A., Lushnikova E., Popova N., Kaledin V., Nikolin V., Zakharenko A., Luzina O., Salakhutdinov N., Lavrik O. Antimetastatic activity of combined topotecan and tyrosyl-DNA phosphodiesterase-1 inhibitor on modeled lewis lung carcinoma. Bull. Exp. Biol. Med. 2019;166:661–666. doi: 10.1007/s10517-019-04413-3. PubMed DOI
Strøm M.B., Haug B.E., Skar M.L., Stensen W., Stiberg T., Svendsen J.S. The pharmacophore of short cationic antibacterial peptides. J. Med. Chem. 2003;46:1567–1570. doi: 10.1021/jm0340039. PubMed DOI
Boullet H., Bentot F., Hequet A., Ganem-Elbaz C., Bechara C., Pacreau E., Launay P., Sagan S., Jolivalt C., Lacombe C., et al. Small antiMicrobial peptide with in vivo activity against sepsis. Molecules. 2019;24:1702. doi: 10.3390/molecules24091702. PubMed DOI PMC
Courtens C., Risseeuw M., Caljon G., Maes L., Martin A., Van Calenbergh S. Amino acid based prodrugs of a fosmidomycin surrogate as antimalarial and antitubercular agents. Bioorg. Med. Chem. 2019;27:729–747. doi: 10.1016/j.bmc.2019.01.016. PubMed DOI
Jomaa H., Wiesner J., Sanderbrand S., Altincicek B., Weidemeyer C., Hintz M., Türbachova I., Eberl M., Zeidler J., Lichtenthaler H.K., et al. Inhibitors of the nonmevalonate pathway of isoprenoid biosynthesis as antimalarial drugs. Science. 1999;285:1573–1576. doi: 10.1126/science.285.5433.1573. PubMed DOI
Ruangweerayut R., Looareesuwan S., Hutchinson D., Chauemung A., Banmairuroi V., Na-Bangchang K. Assessment of the pharmacokinetics and dynamics of two combination regimens of fosmidomycin-clindamycin in patients with acute uncomplicated falciparum malaria. Malaria J. 2008;7:225. doi: 10.1186/1475-2875-7-225. PubMed DOI PMC
Su X., Yi Y., Yan Z., Rosen B.H., Liang B., Winter M.C., Evans I.A., Rotti P.H.G., Yu Y., Gray J.S., et al. In utero and postnatal VX-770 administration rescues multiorgan disease in a ferret model of cystic fibrosis. Sci. Trans. Med. 2019:eaau7531. doi: 10.1126/scitranslmed.aau7531. PubMed DOI PMC
Smith B.E., Wang S.L., Jaime-Figueroa S., Harbin A., Wang J., Hamman B.D., Crews C.M. Differential PROTAC substrate specificity dictated by orientation of recruited E3 ligase. Nat. Commun. 2019;10:131. doi: 10.1038/s41467-018-08027-7. PubMed DOI PMC
Lyu J., Wang S., Balius T., Singh I., Levit A., Moroz Y.S., O’Meara M.J., Che T., Algaa E., Tolmachova K., et al. Ultra-large library docking for discovering new chemotypes. Nature. 2019;566:224. doi: 10.1038/s41586-019-0917-9. PubMed DOI PMC
Liu R., Yue Z., Tsai C.-C., Shen J. Assessing lysine and cysteine reactivities for designing targeted covalent kinase inhibitors. J. Am. Chem. Soc. 2019;141:6553–6560. doi: 10.1021/jacs.8b13248. PubMed DOI PMC
Murugaiah A.M., Subbaiah S.M., Sridhar D., Thangeswaran R., Lakshumanan S., Mathiazhagan A., Salil D., Desai S.S., Susan M., Jenkins M.R., et al. Design, synthesis, and pharmacokinetic evaluation of phosphate and amino acid ester prodrugs for improving the oral bioavailability of the HIV-1 protease inhibitor atazanavir. J. Med. Chem. 2019;62:3553–3574. PubMed
Stoneman M.R., Biener G., Ward R.J., Pediani J.D., Badu D., Eis A., Popa I., Milligan G., Raicu V. A general method to quantify ligand-driven oligomerization from fluorescence-based images. Nat. Methods. 2019 May; doi: 10.1038/s41592-019-0408-9. PubMed DOI PMC
Boosani C.S., Agrawal D.K. PTEN modulators: A patent review. Expert Opin. Ther. Pat. 2013;23:569–580. doi: 10.1517/13543776.2013.768985. PubMed DOI PMC
Lee Y.R., Chen M., Lee J.D., Zhang J., Lin S.Y., Fu T.M., Chen H., Ishikawa T., Chiang S.Y., Katon J., et al. Reactivation of PTEN tumor suppressor for cancer treatment through inhibition of a MYC-WWP1 inhibitory pathway. Science. 2019;364:eaau0159. doi: 10.1126/science.aau0159. PubMed DOI PMC
Li L., Ma L., Wang D., Jia H., Yu M., Gu Y., Shang H., Zou Z. Design and synthesis of matrine derivatives as novel anti-pulmonary fibrotic agents via repression of the TGFβ/Smad pathway. Molecules. 2019;24:1108. doi: 10.3390/molecules24061108. PubMed DOI PMC
Fan R., Chuan D., Hou H., Chen H., Han B., Zhang X., Zhou L., Tong A., Xu J., Guo G. Development of a hybrid nanocarrier-recognizing tumor vasculature and penetrating the BBB for glioblastoma multi-targeting therapy. Nanoscale. 2019 Jun 5; doi: 10.1039/C9NR01320B. PubMed DOI
Wu Y., Beilei W., Junjie W., Shuang Q., Fengming Z., Ziping Q., Feiyang L., Qingwang L., Cheng C., Chen H., et al. Discovery of 2-(4-Chloro-3-(trifluoromethyl)phenyl)-N-(4-((6,7-dimethoxyquinolin-4-yl)oxy)phenyl)acetamide (CHMFL-KIT-64) as a novel orally available potent inhibitor against broad-spectrum mutants of c-KIT kinase for gastrointestinal stromal tumors. J. Med. Chem. 2019 doi: 10.1021/acs.jmedchem.9b00280. PubMed DOI
Connelly C.M., Numata T., Boer R., Moon M.H., Sinniah R.S., Barchi J.J., Ferré-D’Amaré A.R., Schneekloth J.S., Jr. Synthetic ligands for PreQ1 riboswitches provide structural and mechanistic insights into targeting RNA tertiary structure. Nat. Commun. 2019;10:1501. doi: 10.1038/s41467-019-09493-3. PubMed DOI PMC
Andrei S.A., Sijbesma E., Hann M., Davis J., O’Mahony G., Perry M.W., Karawajczyk A., Eickhoff J., Brunsveld L., Doveston R.G., et al. Stabilization of protein-protein interactions in drug discovery. Expert Opin. Drug Discov. 2017;12:925–940. doi: 10.1080/17460441.2017.1346608. PubMed DOI
Sijbesma E., Hallenbeck K.K., Leysen S., de Vink P.J., Skóra L., Jahnke W., Brunsveld L., Arkin M.R., Ottmann C. Site-directed fragment-based screening for the discovery of protein-protein interaction stabilizers. J. Am. Chem. Soc. 2019;141:3524–3531. doi: 10.1021/jacs.8b11658. PubMed DOI
Koh A., De Vadder F., Kovatcheva-Datchary P., Backhed F. From dietary fiber to host physiology: Short-chain fatty acids as key bacterial metabolites. Cell. 2016;165:1332–1345. doi: 10.1016/j.cell.2016.05.041. PubMed DOI
Luu M., Pautz S., Kohl V., Singh R., Romero R., Lucas S., Hofmann J., Raifer H., Vachharajani N., Carrascosa L.C., et al. The short-chain fatty acid pentanoate suppresses autoimmunity by modulating the metabolic epigenetic crosstalk in lymphocytes. Nat. Commun. 2019;10:760. doi: 10.1038/s41467-019-08711-2. PubMed DOI PMC
Saidi L., Rocha D.H.A., Talhi O., Bentarzi Y., Nedjar-Kolli B., Bachari K., Almeida Paz F.A., Helguero L.A., Silva A.M.S. Synthesis of benzophenones and in vitro evaluation of their anticancer potential in breast and prostate cancer cells. ChemMedChem. 2019;14:1041–1048. doi: 10.1002/cmdc.201900127. PubMed DOI
Rossi A., Roviezzo F., Sorrentino R., Riemma M.A., Cerqua I., Bilancia R., Spaziano G., Troisi F., Pace S., Pinto A., et al. Leukotriene-mediated sex dimorphism in murine asthma-like features duringallergensensitization. Pharmacol. Res. 2019;139:182–190. doi: 10.1016/j.phrs.2018.11.024. PubMed DOI
Pace S., Pergola C., Dehm F., Rossi A., Gerstmeier J., Troisi F., Pein H., Schaible A.M., Weinigel C., Rummler S., et al. Androgen-mediated sex bias impairs efficiency of leukotriene biosynthesis inhibitors in males. J. Clin. Investig. 2017;127:3167–3176. doi: 10.1172/JCI92885. PubMed DOI PMC
Pace S., Rossi A., Krauth V., Dehm F., Troisi F., Bilancia R., Weinigel C., Rummler S., Werz O., Sautebin L. Sex differences in prostaglandin biosynthesis inneutrophils during acute inflammation. Sci. Rep. 2017;7:3759. doi: 10.1038/s41598-017-03696-8. PubMed DOI PMC
Trost B.M., Xu S., Sharif E.U. New catalytic asymmetric formation of oxygen heterocycles bearing nucleoside bases at the anomeric carbon. J. Am. Chem. Soc. 2019 doi: 10.1021/jacs.9b06050. PubMed DOI
Birkinshaw R.W., Gong J.N., Luo C.S., Lio D., White C.A., Anderson M.A., Blombery P., Lessene G., Majewski I.J., Thijssen R., et al. Structures of BCL-2 in complex with venetoclax reveal the molecular basis of resistance mutations. Nat. Commun. 2019;10:2385. doi: 10.1038/s41467-019-10363-1. PubMed DOI PMC
Casara P., Davidson J., Claperon A., Le Toumelin-Braizat G., Vogler M., Bruno A., Chanrion M., Lysiak-Auvity G., Le Diguarher T., Starck J.B., et al. S55746 is a novel orally active BCL-2 selective and potent inhibitor that impairs hematological tumor growth. Oncotarget. 2018;9:20075–20088. doi: 10.18632/oncotarget.24744. PubMed DOI PMC
Zoppi V., Hughes S.J., Maniaci C., Testa A., Gmaschitz T., Wieshofer C., Koegl M., Riching K.M., Daniels D.L., Spallarossa A., et al. Iterative design and optimization of initially inactive proteolysis targeting chimeras (PROTACs) identify VZ185 as a potent, fast, and selective von Hippel-Lindau (VHL) based dual degrader probe of BRD9 and BRD7. J. Med. Chem. 2019;62:699–726. doi: 10.1021/acs.jmedchem.8b01413. PubMed DOI PMC