The clinical utility of computational phenotyping for both genetic and rare diseases is increasingly appreciated; however, its true potential is yet to be fully realized. Alongside the growing clinical and research availability of sequencing technologies, precise deep and scalable phenotyping is required to serve unmet need in genetic and rare diseases. To improve the lives of individuals affected with rare diseases through deep phenotyping, global big data interrogation is necessary to aid our understanding of disease biology, assist diagnosis, and develop targeted treatment strategies. This includes the application of cutting-edge machine learning methods to image data. As with most digital tools employed in health care, there are ethical and data governance challenges associated with using identifiable personal image data. There are also risks with failing to deliver on the patient benefits of these new technologies, the biggest of which is posed by data siloing. The Minerva Initiative has been designed to enable the public good of deep phenotyping while mitigating these ethical risks. Its open structure, enabling collaboration and data sharing between individuals, clinicians, researchers and private enterprise, is key for delivering precision public health.

Alberta Children's Hospital Research Institute Calgary AB Canada

Big Data Institute University of Oxford Oxford United Kingdom

Center for Human Genetics University Hospitals Leuven University of Leuven Leuven Belgium

Centre for Population Health Research Curtin University of Technology Perth WA Australia

CHU Nantes Service de Génétique Médicale Nantes France

CIMR Cambridge United Kingdom

Clinical Genetics Group MRC Weatherall Institute of Molecular Medicine University of Oxford John Radcliffe Hospital Headington Oxford United Kingdom

Department of Biology and Medical Genetics 2nd Faculty of Medicine Charles University and University Hospital Prague Czechia

Department of Clinical Genetics Maastricht University Medical Center Maastricht Netherlands

Department of Clinical Neurosciences Western General Hospital Edinburgh United Kingdom

Department of Computer Science University of Toronto and the Hospital for Sick Children Toronto Canada

Department of Congenital Heart Disease and Pediatric Cardiology University Hospital of Schleswig Holstein Campus Kiel Kiel Germany

Department of Genetics King Faisal Specialist Hospital and Research Center Riyadh Saudi Arabia

Department of Genome Science University of Washington School of Medicine Seattle WA United States

Department of Human Genetics Radboud University Medical Center Nijmegen Netherlands

Department of Medical Genetics University and University Hospital Antwerp Antwerp Belgium

Department of Medical Genetics University of Antwerp Antwerp Belgium

Department of Molecular and Human Genetics Baylor College of Medicine Houston TX United States

Department of Paediatrics and Neonates Fiona Stanley Hospital Perth WA Australia

Department of Psychiatry and Behavioral Science University of Washington School of Medicine Seattle WA United States

Division of Human Genetics Level 3 Wernher and Beit North Institute of Infectious Disease and Molecular Medicine Faculty of Health Sciences University of Cape Town Observatory South Africa

Ethox Centre Nuffield Department of Population Health University of Oxford Oxford United Kingdom

Genetic Services of Western Australia King Edward Memorial Hospital Subiaco WA Australia

George A Jervis Clinic and Institute for Basic Research in Developmental Disabilities Staten Island NY United States

Great Ormond Street Hospital for Children NHS Foundation Trust London United Kingdom

Howard Hughes Medical Institute University of Washington Seattle WA United States

Hunter Genetics Waratah NSW Australia

Imagine Institute Paris France

Institut für Genomische Statistik und Bioinformatik Universitätsklinikum Bonn Rheinische Friedrich Wilhelms Universität Bonn Germany

Institute for Biomedical Engineering University of Oxford Oxford United Kingdom

Laboratorio Chamoles Errores Congénitos del Metabolismo Buenos Aires Argentina

Manchester Centre for Genomic Medicine Central Manchester University Hospitals NHS Foundation Trust MAHSC Saint Mary's Hospital Manchester United Kingdom

McKusick Nathans Institute of Genetic Medicine Johns Hopkins University Baltimore MD United States

MRC Human Genetics Unit IGMM University of Edinburgh Western General Hospital Edinburgh United Kingdom

National Organization for Rare Disorders Danbury CT United States

Northern and Yorkshire Cleft Lip and Palate Service Royal Victoria Infirmary Newcastle upon Tyne United Kingdom

Nuffield Department of Women's and Reproductive Health University of Oxford Oxford United Kingdom

Oasi Research Institute IRCCS Troina Italy

Office of Population Health Genomics Public and Aboriginal Health Division Department of Health Government of Western Australia Perth WA Australia

Oregon Health and Science University Portland OR United States

Oxford Centre for Genomic Medicine Oxford United Kingdom

Princess Máxima Center for Pediatric Oncology Utrecht Netherlands

Sir Walter Murdoch School of Policy and International Affairs Murdoch University

Spatial Sciences Science and Engineering Curtin University Perth WA Australia

Telethon Kids Institute and School of Paediatrics and Child Health University of Western Australia Perth WA Australia

The Garvan Institute Sydney NSW Australia

The Jackson Laboratory Farmington CT United States

Victorian Clinical Genetics Service and Murdoch Childrens Research Institute The Royal Children's Hospital Parkville VIC Australia

Wellcome Centre for Ethics and Humanities University of Oxford Oxford United Kingdom

Wellcome Trust Sanger Institute Hinxton Cambridge United Kingdom

Western Australian Register of Developmental Anomalies and Genetic Services of Western Australia King Edward Memorial Subiaco WA Australia

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