Synthesis and study of branched hyaluronic acid with potential anticancer activity
Language English Country Great Britain, England Media print-electronic
Document type Journal Article
PubMed
31426966
DOI
10.1016/j.carbpol.2019.115047
PII: S0144-8617(19)30714-3
Knihovny.cz E-resources
- Keywords
- Aldehyde, Anti-cancer, Conjugate, Hyaluronan, Oligomers,
- MeSH
- Fibroblasts drug effects MeSH
- Hyaluronic Acid chemical synthesis pharmacology toxicity MeSH
- Humans MeSH
- Molecular Structure MeSH
- Cell Line, Tumor MeSH
- Antineoplastic Agents chemical synthesis pharmacology toxicity MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Hyaluronic Acid MeSH
- Antineoplastic Agents MeSH
Conjugates of hyaluronic acid (HA) with biologically active molecules showed great potential in many applications. Oligomers of hyaluronic acid (oliHA) as possible regulators of biological processes and potential anti-cancer therapeutics, were reversibly attached via covalent bond on HA modified with an aldehyde group (HA-CHO) using bis-hydrazido or bis-oxyamino spacers. The structure of the final conjugates (HA-spacer-oliHA) was studied by advanced 2-dimensional NMR techniques in detail. The suggested synthetic strategy is simple, straightforward and can be used for the synthesis of various types of HA or oliHA conjugates. in vitro cytotoxicity assays showed selective activity of HA-spacer-oliHA conjugates against cancer cell lines in comparison with standard human fibroblasts.
References provided by Crossref.org
