Activity measurements and determination of nuclear decay data of 166Ho in the MRTDosimetry project
Language English Country Great Britain, England Media print-electronic
Document type Journal Article
PubMed
31525708
DOI
10.1016/j.apradiso.2019.108826
PII: S0969-8043(19)30598-6
Knihovny.cz E-resources
- Keywords
- Activity standardization, Half-life measurements, Ho-166, MRTDosimetry project, Molecular radiotherapy, γ-spectrometry,
- MeSH
- Radiation Dosage * MeSH
- Holmium analysis MeSH
- Tomography, Emission-Computed, Single-Photon MeSH
- Humans MeSH
- Liver Neoplasms diagnostic imaging radiotherapy MeSH
- Radioisotopes analysis MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Holmium-166 MeSH Browser
- Holmium MeSH
- Radioisotopes MeSH
Holmium-166 is a high-energy β--emitter radionuclide (~ 1.8 MeV) with a short half-life (~26.8h) that offers great potential as an alternative to 90Y for the treatment of liver cancer based on radioembolization. The possibility of quantitative Single Photon Emission Computed Tomography (SPECT) imaging of the main γ-ray emission at 80.6 keV, in addition to strong paramagnetic properties suitable for Magnetic Resonance Imaging (MRI), complement this therapeutic potential. The present paper describes the measurements carried out in three European radionuclide metrology laboratories for primary standardization of 166Ho and new determinations of X- and γ-ray photon-emission intensities in the framework of the European EMPIR project MRTDosimetry. New half-life measurements were also performed.
CEA LIST Laboratoire National Henri Becquerel 91191 Gif sur Yvette Cedex France
Czech Metrology Institute Okruzni 31 638 00 Brno Czech Republic
National Physical Laboratory Hampton Road Teddington Middlesex TW11 0LW United Kingdom
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