A pragmatic approach to the use of inotropes for the management of acute and advanced heart failure: An expert panel consensus
Language English Country Netherlands Media print-electronic
Document type Journal Article
PubMed
31615650
DOI
10.1016/j.ijcard.2019.09.005
PII: S0167-5273(19)32502-1
Knihovny.cz E-resources
- Keywords
- Acute heart failure, Advanced heart failure, Dobutamine, Inodilators, Inotropes, Levosimendan, Milrinone, Norepinephrine,
- MeSH
- Adrenergic beta-Agonists therapeutic use MeSH
- Cardiotonic Agents therapeutic use MeSH
- Consensus MeSH
- Practice Patterns, Physicians' MeSH
- Humans MeSH
- Heart Failure drug therapy MeSH
- Patient Selection MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Adrenergic beta-Agonists MeSH
- Cardiotonic Agents MeSH
Inotropes aim at increasing cardiac output by enhancing cardiac contractility. They constitute the third pharmacological pillar in the treatment of patients with decompensated heart failure, the other two being diuretics and vasodilators. Three classes of parenterally administered inotropes are currently indicated for decompensated heart failure, (i) the beta adrenergic agonists, including dopamine and dobutamine and also the catecholamines epinephrine and norepinephrine, (ii) the phosphodiesterase III inhibitor milrinone and (iii) the calcium sensitizer levosimendan. These three families of drugs share some pharmacologic traits, but differ profoundly in many of their pleiotropic effects. Identifying the patients in need of inotropic support and selecting the proper inotrope in each case remain challenging. The present consensus, derived by a panel meeting of experts from 21 countries, aims at addressing this very issue in the setting of both acute and advanced heart failure.
1st Department of Cardiology Medical University of Gdansk Gdansk Poland
Aristotle University of Thessaloniki Thessaloniki Greece
Cardiology Dept Rigshospitalet University of Copenhagen Copengahen Denmark
Cardiovascular Center Na Homolce Hospital Prague Czech Republic
Complexo Hospitalario Universitario de A Coruña A Coruña Spain
Critical Care Proprietary Products Orion Pharma Espoo Finland
Department of Anesthesiology Almazov National Medical Research Center Saint Petersburg Russia
Department of Cardiology Dokuz Eylul University Faculty of Medicine Izmir Turkey
Department of Cardiology General Hospital Sismanogleio Amalia Fleming Greece
Department of Cardiology North Estonia Medical Center Tallinn Estonia
Department of Cardiovascular Sciences Ospedali Riuniti Ancona Italy
Emergency Medicine University of Helsinki Helsinki University Hospital Helsinki Finland
Heart and Vascular Center Semmelweis University Budapest Hungary
Jesselson Integrated Heart Center Shaare Zedek Medical Center Jerusalem Israel
Transplant Institute Sahlgrenska University Hospital Gothenburg Sweden
Universitätsklinik für Innere Medizin 3 Medizinsche Universität Innsbruck Austria
References provided by Crossref.org