Tumor infiltrating lymphocytes in malignant melanoma - allies or foes?
Language English Country Czech Republic Media print-electronic
Document type Journal Article, Review
PubMed
31649385
DOI
10.5507/bp.2019.048
Knihovny.cz E-resources
- Keywords
- immune check point, melanoma, regulatory lymphocytes, tumor infiltrating lymphocytes,
- MeSH
- Humans MeSH
- Melanoma etiology pathology MeSH
- Skin Neoplasms etiology pathology MeSH
- Lymphocytes, Tumor-Infiltrating physiology MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Review MeSH
This is an overview of current problematics regarding the role of tumor infiltrating lymphocytes (TILs) in malignant melanomas. Various and often conflicting data have been published, correlating tumor type, stage, prognosis, as well as sex and age of patients. This is partly due to heterogeneity in scaling systems and unstandardized TILs grading but also due to changes of tumor-host interactions. Melanomas are an immunologically heterogeneous group with variability of TILs, where distinct gene expression patterns were found in tumors with absent, and/or non- brisk TIL grade versus brisk TIL grade. However, the presence of TILs alone appears to be inadequate for implicating them as immunologically functional. Further characterisation of TIL phenotype and function is warranted. This especially concerns, evaluation of TILs of the suppressor phenotype but rather than as a prognostic factor, more for prediction of targeted immunotherapy.
Department of Pathology CGB Laboratory Ostrava Czech Republic
Department of Pathology University Hospital Ostrava Czech Republic
Institute of Clinical and Molecular Pathology University Hospital Olomouc Olomouc Czech Republic
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