OBJECTIVE: To provide a new perspective on integrated biomedical and psychosocial dementia research. BACKGROUND: Dementia is being recognized as a multifactorial syndrome, but there is little interaction between biomedical and psychosocial approaches. A way to improve scientific knowledge is to seek better understanding of the mechanisms underlying the interaction between biomedical and psychosocial paradigms. One rationale for integrating biomedical and psychosocial research is the discordance between neuropathology and cognitive functioning. The concept of social health might bridge the two paradigms. It relates to how social resources influence the dynamic balance between capacities and limitations. HYPOTHESES: Social health can act as the driver for accessing cognitive reserve, in people with dementia through active facilitation and utilization of social and environmental resources. Thereby we link lifestyle social and opportunities to the brain reserve hypothesis. MANIFESTO: We provide a Manifesto on how to significantly move forward the dementia research agenda.

Alzheimer Center Limburg School for Mental Health and Neurosciences Maastricht University Maastricht the Netherlands

Alzheimer Centrum Limburg School of Mental Health and Neurosciences Psychiatry and Psychology MUMC Maastricht The Netherlands

Charles University FHS CELLO and Gerontologicke Centrum Kobylisy Czechia

Dementia Services Development Centre DSDC Wales Bangor University Ardudwy Bangor UK

Department of Psychiatry Amsterdam University Medical Centers Location VUmc APH Research Institute Amsterdam the Netherlands

Department of Psychology University of Bologna Bologna Italy

Department Psychiatry University Rio Hortega Hospital Spain

Faculty of Health Sciences School of Health and Social Work University of Hull Hull UK

Psychiatric and Mental Health Department University Rio Hortega Hospital and Zamora Hospital Zamora Spain

Scientific Institute for Quality of Healthcare Radboud University Medical Center Nijmegen The Netherlands

The Institute of Mental Health University of Nottingham Innovation Park Nottingham UK

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