MEAN VALUE OF LET FOR ONCOGENIC EFFECTS OF RADON AND ITS PROGENY
Language English Country Great Britain, England Media print
Document type Journal Article
PubMed
31803906
DOI
10.1093/rpd/ncz194
PII: 5658465
Knihovny.cz E-resources
- MeSH
- Alpha Particles * MeSH
- Radon Daughters adverse effects MeSH
- Carcinogenesis * MeSH
- Mesocricetus MeSH
- Humans MeSH
- Linear Energy Transfer * MeSH
- Mice, Inbred C3H MeSH
- Mice MeSH
- Cell Transformation, Neoplastic radiation effects MeSH
- Lung Neoplasms MeSH
- Neoplasms, Radiation-Induced MeSH
- Oncogenes MeSH
- Radon adverse effects MeSH
- Relative Biological Effectiveness * MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Mice MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Radon Daughters MeSH
- Radon MeSH
The topic of the article is to define the average value of linear energy transfer (LET) for carcinogenic effects of radon progeny. The microdosimetric model of boundary specific energy is used. It follows that the effect at high LET should decrease approximately with the third power of LET. This is verified by the analysis of the relationship between radiation effects ratio and LET in published experiments with oncogenic transformation of mammalian cells irradiated with the monoenergetic alpha particles. If these cells are exposed with the radon irradiator, our analysis leads us to conclude that the oncogenic effect of radon progeny is comparable to that of alpha particles with a LET of 75 keV/μm. It is about a quarter lower than the LET value, where the effect of the monoenergetic alpha particles reaches its maximum level. Some implications for lung cancer due to radon inhalation may also be carefully examined.
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