Allogeneic Venous Grafts of Different Origin Used for Portal Vein Reconstruction After Pancreaticoduodenectomy - Experimental Study
Language English Country Greece Media print
Document type Comparative Study, Journal Article
PubMed
31810926
DOI
10.21873/anticanres.13876
PII: 39/12/6603
Knihovny.cz E-resources
- Keywords
- Pancreaticoduodenectomy, allogeneic grafts, computer blood flow simulation, portal vein haemodynamics, portal vein reconstruction,
- MeSH
- Allografts MeSH
- Anastomosis, Surgical methods MeSH
- Hemodynamics MeSH
- Organ Sparing Treatments MeSH
- Cadaver MeSH
- Tissue and Organ Harvesting MeSH
- Pancreaticoduodenectomy * MeSH
- Computer Simulation * MeSH
- Postoperative Complications etiology MeSH
- Swine MeSH
- Pylorus MeSH
- Regional Blood Flow MeSH
- Ultrasonography MeSH
- Organ Size MeSH
- Vena Cava, Inferior anatomy & histology diagnostic imaging physiology transplantation MeSH
- Portal Vein anatomy & histology diagnostic imaging physiology surgery MeSH
- Plastic Surgery Procedures methods MeSH
- Venous Thrombosis etiology MeSH
- Animals MeSH
- Check Tag
- Male MeSH
- Female MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Comparative Study MeSH
BACKGROUND: In clinical medicine, little is known about the use of allografts for portal vein (PV) reconstruction after pancreaticoduodenectomy (PD). Portal and caval systems are physiologically different, therefore the properties of allografts from caval and portal systems were studied here in a pig model. MATERIALS AND METHODS: PD with PV reconstruction with allogeneic venous graft from PV or inferior vena cava (IVC) was performed in 26 pigs. Biochemical analysis and ultrasonography measurements were performed during a 4-week monitoring period. Computer simulations were used to evaluate haemodynamics in reconstructed PV and explanted allografts were histologically examined. RESULTS: The native PV and IVC grafts varied in histological structure but were able to adapt morphologically after transplantation. Computer simulation suggested PV grafts to be more susceptible to thrombosis development. Thrombosis of reconstructed PV occurred in four out of five cases in PV group. CONCLUSION: This study supports the use of allografts from caval system for PV reconstruction in clinical medicine when needed.
Biomedical Center Faculty of Medicine in Pilsen Charles University Pilsen Czech Republic
Department of Anatomy Faculty of Medicine in Pilsen Charles University Pilsen Czech Republic
Department of Mechanics Faculty of Applied Sciences University of West Bohemia Pilsen Czech Republic
Department of Medical Imaging Faculty of Medicine in Pilsen Charles University Pilsen Czech Republic
Department of Surgery Faculty of Medicine in Pilsen Charles University Pilsen Czech Republic
References provided by Crossref.org
