Children with PCNSL and no immunodeficiency have a good outcome when treated by a histological subtype–driven and radiation-free protocol. New treatment guidelines are needed for PCNSL in children and adolescents with an underlying immunodeficiency.

Belarusian Research Center for Pediatric Oncology Hematology and Immunology Minsk Belarus

Bone Marrow Transplantation and Pediatric Hematology and Oncology Wroclaw Medical University Wroclaw Poland

Center for Cancer and Blood Disorders Children's National Medical Center The George Washington University Washington DC

Center for Cancer and Blood Disorders Phoenix Children's Hospital Phoenix AZ

Children's Cancer Center National Center for Child Health and Development Tokyo Japan

Department of Oncology P and A Kyriakou Children's Hospital Athens Greece

Department of Pediatric and Adolescent Oncology Gustave Roussy Cancer Center Paris Sacaly University Villejuif France

Department of Pediatric Hematology and Oncology Charles University and University Hospital Motol Prague Czech Republic

Department of Pediatric Hematology and Oncology Federal Center for Pediatric Hematology Oncology and Immunology Moscow Russia

Department of Pediatric Hematology and Oncology St Anna Children's Hospital Medical University of Vienna Vienna Austria

Department of Pediatric Hematology and Oncology University Children's Hospital School of Medicine University of Belgrade Belgrade Serbia

Department of Pediatric Hematology and Oncology University Hospital Hamburg Eppendorf Hamburg Germany; and

Department of Pediatric Hematology and Oncology University Hospital Leuven Leuven Belgium

Department of Pediatric Hematology and Oncology University Hospital of Valencia Valencia Spain

Department of Pediatric Hematology and Oncology University of Münster Münster Germany

Department of Pediatric Hematology and Oncology University of Padova Padova Italy

Department of Pediatric Oncology and Hematology Yerevan State Medical University and Pediatric Cancer and Blood Disorders Center of Armenia Yerevan Armenia

Department of Pediatrics and Adolescent Medicine Li Ka Shing Faculty of Medicine The University of Hong Kong Queen Mary Hospital Pokfulam Hong Kong

Division of Hematology and Oncology Department of Pediatrics Hospital for Sick Children Toronto ON Canada

Division of Pediatric Hematology and Oncology Department of Pediatrics Weill Cornell Medical College New York NY

Division of Pediatrics Hematology and Oncology University Medical Center Ljubljana Ljubljana Slovenia

Northern Institute for Cancer Research Newcastle University Newcastle United Kingdom

Pediatric Hematology Oncology Research Laboratory and Pediatric Hematology Oncology Unit Division of Pediatrics Department Woman Mother Child Lausanne University Hospital Lausanne Switzerland

Princess Maxima Center for Pediatric Oncology Utrecht The Netherlands

Telethon Kids Cancer Centre Telethon Kids Institute University of Western Australia Perth WA Australia

Blood Adv. 2020 Mar 24;4(6):1012. doi: 10.1182/bloodadvances.2020001770. PubMed

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