We aimed to validate the Czech version of the MATRICS Consensus Cognitive Battery (MCCB). The MCCB is a test battery designed to assess cognitive treatment effects in clinical trials of patients with schizophrenia. The valid, reliable and replicable measurement of cognition in schizophrenia is of substantial importance for such clinical trial studies. We performed a psychometric analysis of the MCCB composite and domain scores based on ROC analysis of 67 schizophrenia patients and 67 age- and education-matched healthy controls from a total sample of 220 controls. Also, we correlated MCCB variables with scales measuring psychosocial functioning (Personal and Social Performance scale; PSP). The internal consistency of all 10 tests in the MCCB battery was good (Cronbach's α = 0.85 (95% CI [0.83, 0.88])). The discriminative validity for the detection of neurocognitive dysfunction in schizophrenia based on the area under the curve of MCCB composite T-score was ≥90% (95% CI [0.85, 0.96]) and all MCCB domains showed ps < .001. The MCCB global composite and the Speed of Processing domain score significantly predicted the PSP ratings. A confirmatory factor analysis on the whole control sample (N = 220) showed an optimal fit for a 6-factor in comparison to 1-factor solution. In conclusion, we found high discriminative validity for the Czech MCCB version, similar to the differentiation of schizophrenia versus healthy control groups in the original MCCB studies. We also established the factorial validity of the MCCB and showed that the overall composite of the MCCB predicts psychosocial functioning in the patient group.

Department of Neurology and Centre of Clinical Neuroscience 1st Faculty of Medicine and General University Hospital Prague Charles University Czech Republic

Department of Psychiatry 1st Faculty of Medicine and General University Hospital Prague Charles University Prague Czech Republic

Semel Institute for Neuroscience and Human Behavior David Geffen School of Medicine at UCLA Los Angeles CA USA; Department of Psychology University of California Los Angeles Los Angeles CA USA

Semel Institute for Neuroscience and Human Behavior David Geffen School of Medicine at UCLA Los Angeles CA USA; Department of Veterans Affairs VISN 22 Mental Illness Research Education and Clinical Center Los Angeles CA USA

The Czech Academy of Sciences Prague Czech Republic

References provided by Crossref.org

Impact of cognitive performance and negative symptoms on psychosocial functioning in Czech schizophrenia patients

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