The fixed-ratio combination (FRC) of a basal insulin and a GLP-1 receptor agonist (GLP-1 RA) has proven to be an effective therapeutic approach. However, physicians face numerous practical questions that cannot be answered by recently published trial results, current guidelines and summaries of product characteristics. In April 2019, a scientific meeting was held with the participation of nine experts from four Central and Eastern European countries to provide expert consensus on the optimal daily use of the insulin glargine and lixisenatide FRC (iGlarLixi). Topics included the positioning and initiation of iGlarLixi and the management of treatment. This paper summarizes the outcomes of the meeting.

1st Department of Endocrinology Békés County Central Hospital Dr Réthy Pál Member Hospital Békéscsaba Hungary

1st Department of Internal Medicine Faculty of Medicine University of Szeged Szeged Hungary

1st Department of Medicine Faculty of Medicine Semmelweis University Budapest Hungary

3rd Department of Internal Medicine 1st Faculty of Medicine Charles University Prague Prague Czech Republic

Clinical Center of Diabetes Nutrition Metabolic Diseases Cluj Napoca Romania

Diabetes Centre Institute for Clinical and Experimental Medicine Prague Czech Republic

National Institute for Endocrinology and Diabetology Lubochna Slovak Republic

Romania National Institute of Diabetes Nutrition and Metabolic Diseases NC Paulescu Carol Davila University of Medicine and Pharmacy Bucharest Bucharest Romania

Sf Spiridon Emergency Hospital Iaşi Romania

Syreon Research Institute Budapest Hungary

Unit of Diabetes Nutrition and Metabolic Diseases Grigore T Popa University of Medicine and Pharmacy Iaşi Romania

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Effectiveness and Safety of iGlarLixi (Insulin Glargine 100 U/mL Plus Lixisenatide) in Type 2 Diabetes According to the Timing of Daily Administration: Data from the REALI Pooled Analysis