The newly proposed International Endocervical Adenocarcinoma Criteria and Classification and its relevance to cervical cytology screening assessed in a prospective 2-year study of 118 cases
Jazyk angličtina Země Anglie, Velká Británie Médium print-electronic
Typ dokumentu časopisecké články
PubMed
32289186
DOI
10.1111/cyt.12831
Knihovny.cz E-zdroje
- Klíčová slova
- human papilloma virus, Papanicolaou test, adenocarcinoma, cervix, cytology, endometrioid endometrial adenocarcinoma, liquid-based cytology,
- MeSH
- adenokarcinom klasifikace diagnóza patologie virologie MeSH
- časná detekce nádoru * MeSH
- cytodiagnostika metody MeSH
- dysplazie děložního hrdla klasifikace diagnóza patologie virologie MeSH
- infekce papilomavirem klasifikace diagnóza patologie virologie MeSH
- lidé MeSH
- Papanicolaouův test metody MeSH
- vaginální stěr metody MeSH
- Check Tag
- lidé MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
BACKGROUND: It is generally acknowledged that interobserver variability for the histological diagnosis of endocervical adenocarcinoma (EA) subtypes is suboptimal. The recently proposed International Endocervical Adenocarcinoma Criteria and Classification (IECC) system is based on the presence of associated human papilloma virus (HPV) infection. It recognises HPV-associated EAs and non-HPV-associated EAs. METHODS: This prospective cytology-histology and molecular genetics-based study investigated the potential effect of IECC being applied to Papanicolaou (Pap) test with regard to the diagnostic accuracy of severe glandular lesions reported at least as adenocarcinoma in situ (AIS). RESULTS: Out of 118 liquid-based cytology Pap tests with AIS+ lesion, complete information on follow-up biopsy and HPV status was available in 51 cases. AIS and EA category correlated with histologically confirmed AIS/EA in 88.5% (23/26) and 70.5% (12/17) of cases, respectively. Interestingly, 93% (40/43) of cases diagnosed as AIS/EA were HPV positive and 7% (3/43) were HPV negative (originating in the cervix, endometrium and adnexa). CONCLUSIONS: Our findings suggest that this approach could possibly divide Pap tests containing severe glandular lesion into two groups: (a) robust diagnosis of HPV-associated EA and (b) non-HPV associated glandular lesions of heterogeneous origin, requiring further clinical preoperative diagnostic workup.
Bioptická laboratoř s r o Pilsen Czech Republic
Cytopathos s r o Bratislava Slovak Republic
Department of Pathology Nemocnice Na Bulovce Praha Czech Republic
Department of Pathology Royal Columbian Hospital University of British Columbia Vancouver BC Canada
Department of Pathology Slovak Medical University Bratislava Slovak Republic
Zobrazit více v PubMed
Stoler M, Bergeron C, Colgan TJ, et al. WHO classification of tumours of the uterine cervix. In: Kurman RJ, Carcangiu ML, Herrington CS, Young RH, eds. WHO Classification of Tumours of Female Reproductive Organs, 4th edn. Lyon: IARC; 2014:172-176.
Stolnicu S, Barsan I, Hoang L, et al. International endocervical adenocarcinoma criteria and classification (IECC): a new pathogenetic classification for invasive adenocarcinomas of the endocervix. Am J Surg Pathol. 2018;42:214-226.
Hodgson A, Park K, Djordjevic B, et al. International endocervical adenocarcinoma criteria and classification: validation and interobserver reproducibility. Am J Surg Pathol. 2019;43:75-83.
Stolnicu S, Barsan I, Hoang L, et al. Diagnostic algorithmic proposal based on comprehensive immunohistochemical evaluation of 297 invasive endocervical adenocarcinomas. Am J Surg Pathol. 2018;42:989-1000.
Solomon D, Davey D, Kurman R, et al. Bethesda 2001 workshop. The 2001 Bethesda system: terminology for reporting results of cervical cytology. JAMA. 2002;287:2114-2119.
Nayar R, Wilbur DC, eds. The Bethesda System for Reporting Cervical Cytology. Definitions, Criteria and Explanatory Notes, 3rd edn. New York, NY: Springer; 2015.
Wilbur DC, Chhieng DC, Guidos B, et al. Epithelial cell abnormalities: glandular. In: Nayar R, Wilbur DC, eds. The Bethesda System for Reporting Cervical Cytology. Definitions, Criteria and Explanatory Notes, 3rd edn. New York, NY: Springer; 2015:194.
Lee KR, Darragh TM, Joste NE, et al. Atypical glandular cells of undetermined significance (AGUS): interobserver reproducibility in cervical smears and corresponding thin-layer preparations. Am J Clin Pathol. 2002;117:96-102.
Moriarty AT, Wilbur D. Those gland problems in cervical cytology: faith or fact? Observations from the Bethesda 2001 terminology conference. Diagn Cytopathol. 2003;28:171-174.
Ozkan F, Ramzy I, Mody DR. Glandular lesions of the cervix on thin-layer Pap tests. Validity of cytologic criteria used in identifying significant lesions. Acta Cytol. 2004;48:372-379.
Wood MD, Horst JA, Bibbo M. Weeding atypical glandular cell look-alikes from the true atypical lesions in liquid-based Pap tests: a review. Diagn Cytopathol. 2007;35:12-17.
Conrad RD, Liu AH, Wentzensen N, et al. Cytologic patterns of cervical adenocarcinomas with emphasis on factors associated with underdiagnosis. Cancer Cytopathol. 2018;126:950-958.
Leeson SC, Alibegashvili T, Arbyn M, et al. HPV testing and vaccination in Europe. J Low Genit Tract Dis. 2014;18:61-69.
de Sanjose S, Quint WG, Alemany L, et al. Human papillomavirus genotype attribution in invasive cervical cancer: a retrospective cross-sectional worldwide study. Lancet Oncol. 2010;11:1048-1056.
Miller RA, Mody DR, Tams KC, Thrall MJ. Glandular lesions of the cervix in clinical practice: a cytology, histology, and human papillomavirus correlation study from 2 institutions. Arch Pathol Lab Med. 2015;139:1431-1436.
Tieben LM, ter Schegget J, Minnaar RP, et al. Detection of cutaneous and genital HPV types in clinical samples by PCR using consensus primers. J Virol Methods. 1993;42:265-279.
Karlsen F, Kalantari M, Jenkins A, et al. Use of multiple PCR primer sets for optimal detection of human papillomavirus. J Clin Microbiol. 1996;34:2095-2100.
Niu S, Molberg K, Thibodeaux J, et al. Challenges in the Pap diagnosis of endocervical adenocarcinoma in situ. J Am Soc Cytopathol. 2019;8:141-148.
Kurman RJ, Ellenson H, Ronnett BM. Blaustein's pathology of the female genital tract, 6th edn. New York, NY: Springer; 2011.
Robboy SJ, Mutter GL, Prat J, Bentley RC, Russell P, Anderson MC. Robboy′s pathology of the female reproductive tract, 2nd edn. Amsterdam: Churchill Livingston/Elsevier; 2009.
Wada T, Ohishi Y, Kaku T, et al. Endocervical adenocarcinoma with morphologic features of both usual and gastric types: clinicopathologic and immunohistochemical analyses and high-risk HPV detection by in situ hybridization. Am J Surg Pathol. 2017;41:696-705.
Pirog EC, Park KJ, Kiyokawa T, et al. Gastric-type adenocarcinoma of the cervix: tumor with wide range of histologic appearances. Adv Anat Pathol. 2019;26:1-12.
Ondič O, Bouda J, Němejcová K, Kajo K, Hegedüs L, Alaghehbandan R. On histologic variability of HPV-associated endocervical adenocarcinomas. Am J Surg Pathol. 2019;43:863-865.
Ostör AG. Early invasive adenocarcinoma of the uterine cervix. Int J Gynecol Pathol. 2000;19:29-38.
Zaino RJ. Symposium part I: adenocarcinoma in situ, glandular dysplasia, and early invasive adenocarcinoma of the uterine cervix. Int J Gynecol Pathol. 2002;21:314-326.
McCluggage WG. Endocervical glandular lesions: controversial aspects and ancillary techniques. J Clin Pathol. 2003;56(3):164-173.
