Ex vivo models for research in extracorporeal membrane oxygenation: a systematic review of the literature
Jazyk angličtina Země Anglie, Velká Británie Médium print
Typ dokumentu časopisecké články, systematický přehled
PubMed
32397884
DOI
10.1177/0267659120907439
Knihovny.cz E-zdroje
- Klíčová slova
- ex vivo models, extracorporeal life support, extracorporeal membrane oxygenation, in vitro,
- MeSH
- lidé MeSH
- mimotělní membránová oxygenace metody MeSH
- výzkumný projekt trendy MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- systematický přehled MeSH
With ongoing progress of components of extracorporeal membrane oxygenation including improvements of oxygenators, pumps, and coating materials, extracorporeal membrane oxygenation became increasingly accepted in the clinical practice. A suitable testing in an adequate setup is essential for the development of new technical aspects. Relevant tests can be conducted in ex vivo models specifically designed to test certain aspects. Different setups have been used in the past for specific research questions. We conducted a systematic literature review of ex vivo models of extracorporeal membrane oxygenation components. MEDLINE and Embase were searched between January 1996 and October 2017. The inclusion criteria were ex vivo models including features of extracorporeal membrane oxygenation technology. The exclusion criteria were clinical studies, abstracts, studies in which the model of extracorporeal membrane oxygenation has been reported previously, and studies not reporting on extracorporeal membrane oxygenation components. A total of 50 studies reporting on different ex vivo extracorporeal membrane oxygenation models have been identified from the literature search. Models have been grouped according to the specific research question they were designed to test for. The groups are focused on oxygenator performance, pump performance, hemostasis, and pharmacokinetics. Pre-clinical testing including use of ex vivo models is an important step in the development and improvement of extracorporeal membrane oxygenation components and materials. Furthermore, ex vivo models offer valuable insights for clinicians to better understand the consequences of choice of components, setup, and management of an extracorporeal membrane oxygenation circuit in any given condition. There is a need to standardize the reporting of pre-clinical studies in this area and to develop best practice in their design.
Critical Care Research Group Prince Charles Hospital Brisbane QLD Australia
Department of Cardiothoracic Anesthesia and Intensive Care San Raffaele Hospital Milan Italy
Department of Critical Care Guy's and St Thomas' NHS Foundation Trust London UK
Department of Intensive Care Hôpital Erasme Université Libre de Bruxelles Brussels Belgium
Department of Internal Medicine 2 University Hospital Regensburg Regensburg Germany
Department of Pulmonology Intensive Care Medicine Paracelsus Medical University Nuremberg Germany
Pediatric Intensive Care Unit Children's Hospital Bambino Gesù IRCCS Rome Italy
Perfusion Department University Hospital Gasthuisberg Louvain Belgium
U O C Anestesia e Rianimazione 1 Fondazione IRCCS Policlinico San Matteo Pavia Italy