Functional gait disorders: A sign-based approach
Language English Country United States Media print-electronic
Document type Journal Article, Review
PubMed
32482839
PubMed Central
PMC7455329
DOI
10.1212/wnl.0000000000009649
PII: WNL.0000000000009649
Knihovny.cz E-resources
- MeSH
- Walking MeSH
- Humans MeSH
- Gait Disorders, Neurologic diagnosis therapy MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Review MeSH
Functional gait disorders are common in clinical practice. They are also usually disabling for affected individuals. The diagnosis is challenging because no single walking pattern is pathognomonic for a functional gait disorder. Establishing a diagnosis is based not primarily on excluding organic gait disorders but instead predominantly on recognizing positive clinical features of functional gait disorders, such as an antalgic, a buckling, or a waddling gait. However, these features can resemble and overlap with organic gait disorders. It is therefore necessary to also look for inconsistency (variations in clinical presentation that cannot be reconciled with an organic lesion) and incongruity (combination of symptoms and signs that is not seen with organic lesions). Yet, these features also have potential pitfalls as inconsistency can occur in patients with dystonic gait or those with freezing of gait. Similarly, patients with dystonia or chorea can present with bizarre gait patterns that may falsely be interpreted as incongruity. A further complicating factor is that functional and organic gait disorders may coexist within the same patient. To improve the diagnostic process, we present a sign-based approach-supported by videos-that incorporates the diverse clinical spectrum of functional gait disorders. We identify 7 groups of supportive gait signs that can signal the presence of functional gait disorders. For each group of signs, we highlight how specific clinical tests can bring out the inconsistencies and incongruencies that further point to a functional gait disorder.
See more in PubMed
Edwards MJ, Bhatia KP. Functional (psychogenic) movement disorders: merging mind and brain. Lancet Neurol 2012;11:250–260. PubMed
Baik JS, Lang AE. Gait abnormalities in psychogenic movement disorders. Mov Disord 2007;22:395–399. PubMed
Baizabal-Carvallo JF, Alonso-Juarez M, Jankovic J. Functional gait disorders, clinical phenomenology, and classification. Neurol Sci 2019;41:911–915. PubMed
Stone J, Carson A, Duncan R, et al. . Which neurological diseases are most likely to be associated with “symptoms unexplained by organic disease.” J Neurol 2012;259:33–38. PubMed
Balint B, van Winsen LML, Bhatia KP, Bloem BR. Psychogenic movement disorders: gait is a give-away!. Mov Disord Clin Prac 2014;1:110–111. PubMed PMC
Nicholson TR, Aybek S, Craig T, et al. . Life events and escape in conversion disorder. Psychol Med 2016;46:2617–2626. PubMed PMC
Ludwig L, Pasman JA, Nicholson T, et al. . Stressful life events and maltreatment in conversion (functional neurological) disorder: systematic review and meta-analysis of case-control studies. Lancet Psychiatry 2018;5:307–320. PubMed
Morgante F, Edwards MJ, Espay AJ. Psychogenic movement disorders. Continuum (Minneap Minn) 2013;19:1383–1396. PubMed PMC
American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, 5th ed. Washington, DC: American Psychiatric Association; 2013.
Espay AJ, Aybek S, Carson A, et al. . Current concepts in diagnosis and treatment of functional neurological disorders. JAMA Neurol 2018;75:1132–1141. PubMed PMC
Hallett M. Psychogenic movement disorders. Eur Neuropsychopharm 2015;25:S153.
Nonnekes J, Goselink RJM, Ruzicka E, Fasano A, Nutt JG, Bloem BR. Neurological disorders of gait, balance and posture: a sign-based approach. Nat Rev Neurol 2018;14:183–189. PubMed
Hayes MW, Graham S, Heldorf P, de Moore G, Morris JGL. A video review of the diagnosis of psychogenic gait: appendix and commentary. Mov Disord 1999;14:914–921. PubMed
Gupta A, Lang AE. Psychogenic movement disorders. Curr Opin Neurol 2009;22:430–436. PubMed
Araujo R, van de Warrenburg B, Lang A, Lees A, Bloem B. The Waiting Room: neurological observations made outside the movement disorder specialist's consulting office. Pract Neurol 2019;19:295–301. PubMed
Boogaarts HD, Abdo WF, Bloem BR. “Recumbent” gait: relationship to the phenotype of “astasia-abasia?” Mov Disord 2007;22:2121–2122. PubMed
Nonnekes J, Goselink R, Weerdesteyn V, Bloem BR. The retropulsion test: a good evaluation of postural instability in Parkinson's disease? J Parkinsons Dis 2015;5:43–47. PubMed
Albanese A. The clinical expression of primary dystonia. J Neurol 2003;250:1145–1151. PubMed
Nonnekes J, Ruzicka E, Nieuwboer A, Hallett M, Fasano A, Bloem BR. Compensation strategies for gait impairments in Parkinson disease: a review. JAMA Neurol 2019;76:718–725. PubMed
Ramos VF, Karp BI, Hallett M. Tricks in dystonia: ordering the complexity. J Neurol Neurosurg Psychiatry 2014;85:987–993. PubMed PMC
Nonnekes J, Janssen S, Bloem BR. Superficial brain stimulation to overcome freezing of gait in Parkinson disease. Neurology 2017;88:1681–1682. PubMed
Ruzicka E, Zarubova K, Nutt JG, Bloem BR. “Silly walks” in Parkinson's disease: unusual presentation of dopaminergic-induced dyskinesias. Mov Disord 2011;26:1782–1784. PubMed PMC
Wilcox RA, Winkler S, Lohmann K, Klein C. Whispering dysphonia in an Australian family (DYT4): a clinical and genetic reappraisal. Mov Disord 2011;26:2404–2408. PubMed
McKeon A, Robinson MT, McEvoy KM, et al. . Stiff-man syndrome and variants: clinical course, treatments, and outcomes. Arch Neurol 2012;69:230–238. PubMed
Brown P, Rothwell JC, Marsden CD. The stiff leg syndrome. J Neurol Neurosurg Psychiatry 1997;62:31–37. PubMed PMC
Simon DK, Nishino S, Scammell TE. Mistaken diagnosis of psychogenic gait disorder in a man with status cataplecticus (“limp man syndrome”). Mov Disord 2004;19:838–840. PubMed
Daum C, Gheorghita F, Spatola M, et al. . Interobserver agreement and validity of bedside “positive signs” for functional weakness, sensory and gait disorders in conversion disorder: a pilot study. J Neurol Neurosur Ps 2015;86:425–430. PubMed
Laub HN, Dwivedi AK, Revilla FJ, Duker AP, Pecina-Jacob C, Espay AJ. Diagnostic performance of the “huffing and puffing” sign in functional (psychogenic) movement disorders. Mov Disord Clin Prac 2015;2:29–32. PubMed PMC
Okun MS, Rodriguez RL, Foote KD, Fernandez HH. The “chair test” to aid in the diagnosis of psychogenic gait disorders. Neurologist 2007;13:87–91. PubMed