Follicle Stimulating Hormone Inhibits the Expression of p53 Up-Regulated Modulator of Apoptosis Induced by Reactive Oxygen Species Through PI3K/Akt in Mouse Granulosa Cells
Jazyk angličtina Země Česko Médium print-electronic
Typ dokumentu časopisecké články
PubMed
32584135
PubMed Central
PMC8549883
DOI
10.33549/physiolres.934421
PII: 934421
Knihovny.cz E-zdroje
- MeSH
- apoptóza fyziologie MeSH
- folikulární buňky účinky léků metabolismus MeSH
- folikuly stimulující hormon farmakologie MeSH
- fosfatidylinositol-3-kinasy třídy I metabolismus MeSH
- modely nemocí na zvířatech MeSH
- myši inbrední ICR MeSH
- myši MeSH
- nádorové supresorové proteiny metabolismus MeSH
- ovariální folikul účinky léků metabolismus MeSH
- primární buněčná kultura MeSH
- proteiny regulující apoptózu metabolismus MeSH
- protoonkogenní proteiny c-akt metabolismus MeSH
- reaktivní formy kyslíku metabolismus MeSH
- signální transdukce MeSH
- zvířata MeSH
- Check Tag
- myši MeSH
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- Akt1 protein, mouse MeSH Prohlížeč
- folikuly stimulující hormon MeSH
- fosfatidylinositol-3-kinasy třídy I MeSH
- nádorové supresorové proteiny MeSH
- Pik3ca protein, mouse MeSH Prohlížeč
- proteiny regulující apoptózu MeSH
- protoonkogenní proteiny c-akt MeSH
- PUMA protein, mouse MeSH Prohlížeč
- reaktivní formy kyslíku MeSH
In mammalian ovaries, follicular atresia occurs periodically and destroys almost all the follicles in the ovary. Follicle-stimulating hormone (FSH) acts as the primary survival factor during follicular atresia by preventing apoptosis in granulosa cells (GCs). Many studies have demonstrated that oxidative stress-induced apoptosis is a main cause of follicular atresia. Reactive oxygen species (ROS)-induced GCs apoptosis is regulated by a variety of signaling pathways involving numerous genes and transcription factors. Therefore, we examined whether FSH inhibits the expression of p53 up-regulated modulator of apoptosis (PUMA) induced by reactive oxygen species (ROS) through phosphoinositide 3-kinase (PI3K) / protein kinase B (AKT) in mouse GCs. In vivo study: thirty-two-mice were randomly assigned to four groups and given FSH. We found that FSH can inhibit the 3-nitropropionic acid (3-NP) induced apoptosis and PUMA expression in mRNA level. Moreover, In vitro experiment, we found that FSH can inhibit the H(2)O(2)-induced apoptosis and PUMA expression in mRNA level. Additionally, we also found that PI3K/AKT inhibitor LY294002 abolished the downregulation of PUMA mRNA by FSH in vitro, In conclusion, FSH inhibit the expression of PUMA induced by ROS through PI3K/AKT pathway in vivo and vitro.
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