Air pollution and molecular changes in age-related diseases
Language English Country England, Great Britain Media print-electronic
Document type Journal Article, Review
- Keywords
- Outdoor air pollution, aging, exposure, oxidative stress, particulate matter,
- MeSH
- Air Pollutants * analysis toxicity MeSH
- Humans MeSH
- MicroRNAs * MeSH
- Particulate Matter analysis MeSH
- Aging MeSH
- Air Pollution * adverse effects analysis MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Review MeSH
- Names of Substances
- Air Pollutants * MeSH
- MicroRNAs * MeSH
- Particulate Matter MeSH
Assessment of the impact that air contaminants have on health is difficult as this is a complex mixture of substances that varies depending on the time and place. There are many studies on the association between air pollution and increased morbidity and mortality. Before the effect of polluted air is manifested at the level of the organs, an impact can be observed at the molecular level. These include some new biomarkers, like a shortening of the mean telomere length in DNA, dysregulation of gene expression caused by microRNA levels or a variation in the copy number of mitochondrial DNA. These changes may predispose individuals to premature development of age-related diseases and consequently to shortening of life. The common attribute, shared by changes at the molecular level and the development of diseases, is the presence of oxidative stress.
Centre for Epidemiological Research University of Ostrava Ostrava Czech Republic
Department of Epidemiology and Public Health University of Ostrava Ostrava Czech Republic
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