Objectives: To analyze the impact of polycyclic aromatic hydrocarbons (PAHs) in ambient air at the time of delivery and five years of age on cognitive development in five year old children. Materials and Methods: Two cohorts of children born in the years 2013 and 2014 from Karvina (Northern Moravia, n = 70) and Ceske Budejovice (Southern Bohemia, n = 99) were studied at the age of five years for their cognitive development related to the exposure to PAHs, determined in the ambient air as the concentration of benzo[a]pyrene (B[a]P) and OH-PAH (hydroxy-PAH) metabolites in urine of the newborns at the time of delivery. As psychological tests, the Bender Visual Motor Gestalt Test (BG test) and the Raven Colored Progressive Matrices (RCPM test) were used. Results: Concentrations of B[a]P in the third trimester of mother's pregnancies were 6.1 ± 4.53 ng/m3 in Karvina, and 1.19 ± 1.28 ng/m3 (p < 0.001) in Ceske Budejovice. Neither the outcome of the RCPM test nor the BG test differed between children in Karvina vs. Ceske Budejovice, or boys vs. girls. Cognitive development in five year old children was affected by the higher exposure to PM2.5 during the third trimester in girls in Karvina. Conclusions: We did not observe any significant effect of prenatal PAH exposure on psychological cognitive tests in five year old children.

Faculty of Food and Biochemical Technology University of Chemistry and Technology 166 28 Prague Czech Republic

Faculty of Health and Social Sciences University of South Bohemia 370 05 Ceske Budejovice Czech Republic

Hospital Ceske Budejovice a s 370 01 Ceske Budejovice Czech Republic

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Sram R.J. New ethical problems related to environmental pollution and behavioral changes in human populations. In: Sram R.J., Bulyzhenkov V., Prilipko L., Christen Y., editors. Ethical Issues of Molecular Genetics in Psychiatry. Springer; Berlin, Germany: 1991. pp. 94–105.

Saundres C.R., Shockley D.C., Knuckles M.E. Behavioral effects induced by acute exposure to benzo(a)pyrene in F-344 rats. Neurotox. Res. 2001;3:557–579. doi: 10.1007/BF03033211. PubMed DOI

Perera F.P., Rauh V., Tsai W.Y., Kinney P., Camann D., Barr D., Bernert T., Garfinkel R., Tu Y.H., Diaz D., et al. Effects of transplacental exposure to environmental pollutans on birth outcomes in a multiethnic population. Environ. Health Perspect. 2003;111:201–205. doi: 10.1289/ehp.5742. PubMed DOI PMC

Bayley N. Bayley Scales of Infant Development. 2nd ed. Psychosociological Corp; San Antonio, TX, USA: 1993.

Perera F.P., Rauh V., Whyatt R.M., Tsai W.Y., Tang D., Diaz D., Hoepner L., Barr D., Tu Y.H., Camann D., et al. Effect of prenatal exposure to airborne polycyclic aromatic hydrocarbons on neurodevelopment in the first 3 years of life among inner/city children. Environ. Health Perspect. 2006;114:1287–1292. doi: 10.1289/ehp.9084. PubMed DOI PMC

Perera F.P., Li Z., Whyatt R., Hoepner L., Wang S., Camann D., Rauh V. Prenatal airborne polycyclic aromatic hydrocarbon exposure and child IQ at age 5 years. Pediatrics. 2009;124:e195–e202. doi: 10.1542/peds.2008-3506. PubMed DOI PMC

Perera F.P., Tang D., Wang S., Vishnevetsky J., Zhang B., Diaz D., Camann D., Rauh V. Prenatal polycyclic aromatic hydrocarbon (PAH) exposure and child behavior at age 6-7 years. Environ. Health Perspect. 2012;120:921–926. doi: 10.1289/ehp.1104315. PubMed DOI PMC

Peterson B.S., Rauh V.A., Bansai R., Hao X., Toth Z., Nati G., Walsh K., Miller R.L., Arias F., Semanek D., et al. Effects of prenatal exposure to air pollutants (polycyclic aromatic hydrocarbons) on development of brain white matter, cognition, and behavior in later childhood. JAMA Psychiatry. 2015;72:531–540. doi: 10.1001/jamapsychiatry.2015.57. PubMed DOI PMC

Jedrychowski W., Whyatt R.M., Camann D., Bawle U.V., Peki K., Spengler J., Dumyahn T.S., Penar A., Perera F.F. Effect of prenatal PAH exposure on birth outcomes and neurocognitive development in a cohort of newborns in Poland. Study design and preliminary ambient data. Int J. Occup. Med. Environ. Health. 2003;16:21–29. PubMed

Edwards S.C., Jedrychowski W., Butscher M., Camann D., Kieltyka A., Mróz E., Flak E., Li Z., Wang S., Rauh V., et al. Prenatal exposure to airborne polycyclic aromatic hydrocarbons and children intelligence at 5 years of age in a prospective cohort study in Poland. Environ. Health Perspect. 2010;118:1326–1331. doi: 10.1289/ehp.0901070. PubMed DOI PMC

Hack M., Breslau N., Weissman B., Aram D., Klein N., Borawski-Clark E. Effect of very low birth weight and subnormal head size on cognitive ability at school age. N. Engl. J. Med. 1991;325:231–237. doi: 10.1056/NEJM199107253250403. PubMed DOI

Jedrychowski W.A., Perera F.P., Camann D., Spengler J., Butscher M., Mroz E., Majewska R., Flak E., Jacek R., Sowa A. Prenatal exposure to polycyclic aromatic hydrocarbons and cognitive dysfunction in children. Environ. Sci. Pollut. Res. 2015;22:3631–3639. doi: 10.1007/s11356-014-3627-8. PubMed DOI PMC

Sram R.J., Ambroz A., Dostal M., Honkova K., Hajslova J., Pulkrabova J., Urbancova K., Kosek V., Veleminsky M., Jr. The Ostrava Region, Czech Republic: Impact of air pollution to children health. Public Health Panor. 2017;3:156–164.

Ambrož A., Vlkova V., Rossner P., Rossnerova A., Svecova V., Milcova A., Pulkrabova J., Hajslova J., Veleminsky M., Solansky I., et al. impact of air pollution on oxidative DNA damage and lipid peroxidation in mothers and their newborns. Int. J. Hyg. Environ. Health. 2016;219:545–556. doi: 10.1016/j.ijheh.2016.05.010. PubMed DOI

Topinka J., Rossner P., Milcova A., Schmuczerova J., Svecova V., Šrám R.J. DNA adducts and oxidative DNA damage induced by organic extracts from PM2.5 in an acellular assay. Toxicol. Lett. 2011;202:186–192. doi: 10.1016/j.toxlet.2011.02.005. PubMed DOI

Czech Hydrometeorological Institute (CHMI) [(accessed on 31 August 2020)];2016 Available online: http://portal.chmi.cz/files/portal/docs/uoco/isko/tab_roc/2014_enh/index_GB.html.

Lankova D., Urbancova K., Sram R.J., Hajslova J., Pulkrabova J. A novel strategy for the determination of polycyclic aromatic hydrocarbon monohydroxylated metabolites in urine using ultra-high-performance liquid chromatography with tandem mass spectrometry. Anal. Bioanal. Chem. 2016;408:2515–2525. doi: 10.1007/s00216-016-9350-1. PubMed DOI

Strnadova M. Bender-Gestalt Test: Příručka pro Administraci, Interpretaci a Vyhodnocení Testu. Psychodiagnostické a Didaktické Testy; Bratislava, Czechoslovakia: 1974.

Raven J.C., Court J.H., Raven J.C. Manual for Raven’s Progressive Matrices and Vocabulary Scales—Section 2: Coloured Progressive Matrices. Oxford Psychologists Press; Oxford, UK: 1990.

Szumilas M. Explaining Odds Ratios. J. Can. Acad. Child. Adolesc. Psychiatry. 2010;19:227–229. PubMed PMC

Blazkova B., Pastorkova A., Solansky I., Veleminsky M., Jr., Sram R.J. The impact of cesarean delivery and vaginal delivery was analyzed on psychological cognitive test results in 5 years old children. In preparation. PubMed PMC

Czech Statistical Institute The Level of Population Education According to Population Census—2011. [(accessed on 5 May 2020)]; (In Czech). Available online: https://www.czso.cz/documents/10180/20536250/17023214.pdf/7545a15a-8565-458b-b4e3-e8bf43255b12?version=1.1.

Lovasi G.S., Elred-Skemp N., Quinn J.W., Chang H., Raugh V.A., Rundle A., Orjuela M.A., Perera F.P. Neighborhood social context and individual polycyclic aromatic hydrocarbon exposures associated with child cognitive test scores. J. Child Fam. Stud. 2014;23:785–799. doi: 10.1007/s10826-013-9731-4. PubMed DOI PMC

Genkinger J.M., Stigter L., Jędrychowski W., Huang T.-J., Wang S., Roen E.L., Majewska R., Kieltyka A., Mroz E., Perera F.P. Prenatal polycyclic aromatic hydrocarbon (PAH) exposure, antioxidant levels and behavioral development of children ages 6–9. Environ. Res. 2015;140:136–144. doi: 10.1016/j.envres.2015.03.017. PubMed DOI PMC

Galton F. The history of twins, as a criterion of the relative powers of nature and nurture (1,2) Int. J. Epidemiol. 2012;41:905–911. doi: 10.1093/ije/dys097. PubMed DOI

Neisser U., Boodoo G., Bouchard T., Jr., Boykin A., Brody N., Ceci S., Halpern D.F., Loehlin J.C., Perloff R., Sternberg R.J., et al. Intelligence: Knowns and unknowns. Am. Psychol. 1996;51:77–101. doi: 10.1037/0003-066X.51.2.77. DOI