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Molecularly imprinted polymers in biological applications

. 2020 Dec ; 69 (6) : 406-419. [epub] 20201001

Language English Country England, Great Britain Media print-electronic

Document type Journal Article, Review

Grant support
Biofilms Research Center for Biointerfaces
721297 Horizon 2020 Framework Programme
20160165 Knowledge Foundation
Malmö University
Allmänna Sjukhusets i Malmö Stiftelse för Bekämpande av Cancer

Molecularly imprinted polymers (MIPs) are currently widely used and further developed for biological applications. The MIP synthesis procedure is a key process, and a wide variety of protocols exist. The templates that are used for imprinting vary from the smallest glycosylated glycan structures or even amino acids to whole proteins or bacteria. The low cost, quick preparation, stability and reproducibility have been highlighted as advantages of MIPs. The biological applications utilizing MIPs discussed here include enzyme-linked assays, sensors, in vivo applications, drug delivery, cancer diagnostics and more. Indeed, there are numerous examples of how MIPs can be used as recognition elements similar to natural antibodies.

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