Drug-loading capacity of polylactide-based micro- and nanoparticles - Experimental and molecular modeling study
Language English Country Netherlands Media print-electronic
Document type Journal Article
PubMed
33130219
DOI
10.1016/j.ijpharm.2020.120031
PII: S0378-5173(20)31016-4
Knihovny.cz E-resources
- Keywords
- All-atom molecular dynamics simulation, Biodegradable polymers, Curcumin loaded polymeric nanoparticles, Drug-loading capacity, Drug-polymer matrix interactions, Polylactide nanoparticles,
- MeSH
- Pharmaceutical Preparations * MeSH
- Nanoparticles * MeSH
- Drug Carriers MeSH
- Polyesters MeSH
- Polyethylene Glycols MeSH
- Particle Size MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Pharmaceutical Preparations * MeSH
- Drug Carriers MeSH
- poly(lactide) MeSH Browser
- Polyesters MeSH
- Polyethylene Glycols MeSH
Micro- and nanostructures prepared from biodegradable homopolymers and amphiphilic block copolymers (AmBCs) have found application as drug-delivery systems (DDSs). The ability to accumulate a drug is a very important parameter characterizing a given DDS. This work focuses on the impact of DDS size, the packing of polymer chains in the DDS, and drug - polymer matrix compatibility on the hydrophobic drug - loading capacity (DLC) of nano/microcarriers prepared from a biodegradable polymer or its copolymer. Using experimental measurements in combination with atomistic molecular dynamics simulations, an analysis of curcumin encapsulation in microspheres (MSs) from polylactide (PLA) homopolymer and nanoparticles (NPs) from PLA-block-poly(2-methacryloyloxyethylphosphorylcholine) AmBC was performed. The results show that curcumin has good affinity for the PLA matrix due to its hydrophobic nature. However, the DLC value is limited by the fact that curcumin only accumulates in the peripheral part of these structures. Such uneven drug distribution in the PLA matrix results from the non-homogeneous density of MSs (non-uniform packing of the polymer chains in the coil). The results also indicate that the MSs can retain a greater amount of hydrophobic drug compared to the NPs, which is associated with the formation of drug aggregates inside the PLA microparticles.
Department of Applied Chemistry University of Hyogo 2167 Shosha Himeji Hyogo 671 2280 Japan
Jagiellonian University Faculty of Chemistry Gronostajowa 2 30 387 Kraków Poland
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